| Gene Information | |
|---|---|
| Gene Name | COL8A2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 703 |
| Protein Names | Collagen alpha-2(VIII) chain (Endothelial collagen) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000171812 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P25067 |
| Gene Card | COL8A2 |
| Uniprot ID | P25067 |
| Pfam | PF00386; PF01391 |
| In ASD | no |
| Allosteric Prediction | no (-1.242947447) |
| Ortholog in Animals | Alpaca_ COL8A2 ( ortholog_one2one ) Dog_ COL8A2 ( ortholog_one2one ) GuineaPig_ COL8A2 ( ortholog_one2one ) Macaque_ COL8A2 ( ortholog_one2one ) Mouse_ Col8a2 ( ortholog_one2one ) Pig_ COL8A2 ( ortholog_one2one ) Rat_ Col8a2 ( ortholog_one2one ) Rabbit_ COL8A2 ( ortholog_one2one ) |
| Ohnologs | COL9A3, COL9A1, COL21A1 |
| Paralogs | COL10A1, OTOL1, ADIPOQ, COL19A1, C1QTNF5, COL8A1, C1QB, C1QL3, C1QTNF7, C1QTNF6, C1QTNF1, C1QTNF8, C1QA, C1QL4, PDCD7, C1QTNF3, C1QL2, C1QL1, C1QTNF9, C1QTNF9B, C1QC, C1QTNF2, C1QTNF4 |
| Tissue | NA |
| Tissue Specificity | Expressed primarily in the subendothelium of large blood vessels. Also expressed in arterioles and venules in muscle, heart, kidney, spleen, umbilical cord, liver and lung and is also found in connective tissue layers around hair follicles, around nerve bundles in muscle, in the dura of the optic nerve, in cornea and sclera, and in the perichondrium of cartilaginous tissues. In the kidney, expressed in mesangial cells, glomerular endothelial cells, and tubular epithelial cells. Also expressed in mast cells, and in astrocytes during the repair process. Expressed in Descemet's membrane. {ECO:0000269|PubMed:10686422, ECO:0000269|PubMed:17888087}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs115156902 rs75864656 rs369487110 rs199786966 rs201235688 rs80358191 rs117860804 rs145553904 rs200767854 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix, basement membrane. |
| Mouse PG classification | HPG |
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