Gene Information
Gene NamePIG7
OrganismHomo sapiens (Human)
Gene Length161
Protein NamesLipopolysaccharide-induced tumor necrosis factor-alpha factor (LPS-induced TNF-alpha factor) (Small integral membrane protein of lysosome/late endosome) (p53-induced gene 7 protein)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ99732
Gene CardLITAF
Uniprot IDQ99732
PfamPF10601
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityUbiquitously and abundantly expressed. Expressed predominantly in the placenta, peripheral blood leukocytes, lymph nodes and spleen. {ECO:0000269|PubMed:10200294, ECO:0000269|PubMed:11274176}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs141862602  rs4280262  rs104894519  rs104894520  rs104894521  rs104894522 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:15793005}. Nucleus {ECO:0000269|PubMed:15793005, ECO:0000269|PubMed:16954198}. Lysosome membrane {ECO:0000269|PubMed:11274176, ECO:0000269|PubMed:27582497};
Peripheral membrane protein {ECO:0000269|PubMed:11274176};
Cytoplasmic side {ECO:0000269|PubMed:11274176}. Early endosome membrane {ECO:0000269|PubMed:21896645, ECO:0000269|PubMed:23166352, ECO:0000269|PubMed:27582497}. Late endosome membrane {ECO:0000269|PubMed:27582497}. Endosome membrane {ECO:0000269|PubMed:27927196};
Peripheral membrane protein {ECO:0000269|PubMed:27927196};
Cytoplasmic side {ECO:0000269|PubMed:27927196}. Cell membrane {ECO:0000269|PubMed:16118794, ECO:0000269|PubMed:27582497};
Peripheral membrane protein {ECO:0000269|PubMed:27582497};
Cytoplasmic side {ECO:0000269|PubMed:27582497}. Golgi apparatus membrane {ECO:0000269|PubMed:16118794}. Note=Associated with membranes of lysosomes, early and late endosomes (PubMed:11274176, PubMed:27927196, PubMed:27582497). Can translocate from the cytoplasm into the nucleus (PubMed:15793005). Detected at Schmidt-Lanterman incisures and in nodal regions of myelinating Schwann cells (By similarity). {ECO:0000250|UniProtKB:Q9JLJ0, ECO:0000269|PubMed:11274176, ECO:0000269|PubMed:15793005, ECO:0000269|PubMed:27582497, ECO:0000269|PubMed:27927196}.
Mouse PG classificationNA
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