| Gene Information | |
|---|---|
| Gene Name | PRPS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 318 |
| Protein Names | Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase I) (PRS-I) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 8 ( ENSG00000147224 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P60891 |
| Gene Card | PRPS1 |
| Uniprot ID | P60891 |
| Pfam | PF14572; PF13793 |
| In ASD | yes |
| Allosteric Prediction | yes (0.985476049) |
| Ortholog in Animals | Alpaca_ PRPS1 ( ortholog_one2one ) Dog_ PRPS1 ( ortholog_one2one ) GuineaPig_ PRPS1 ( ortholog_one2one ) Macaque_ PRPS1 ( ortholog_one2one ) Mouse_ Prps1 ( ortholog_one2many ) Mouse_ Prps1l3 ( ortholog_one2many ) Pig_ PRPS1 ( ortholog_one2one ) Rabbit_ PRPS1 ( ortholog_one2one ) |
| Ohnologs | PRPS2 |
| Paralogs | PRPS1L1, PRPS2, PRPSAP1, PRPSAP2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.020295(Chimpanzee);NULL(Mouse);NULL(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2H06 (X-ray 2.20A ) 2H07 (X-ray 2.20A ) 2H08 (X-ray 2.50A ) 2HCR (X-ray 2.20A ) 3EFH (X-ray 2.60A ) 3S5J (X-ray 2.02A ) 4F8E (X-ray 2.27A ) 4LYG (X-ray 3.00A ) 4LZN (X-ray 2.14A ) 4LZO (X-ray 3.31A ) 4M0P (X-ray 2.11A ) 4M0U (X-ray 2.74A ) |
| DBSNP | rs869025594 rs80338731 rs137852542 rs180177151 rs180177152 rs137852540 rs80338732 rs137852543 rs80338675 rs398122855 rs80338676 rs137852541 rs137852544 rs137852545 rs180177153 rs180177154 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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