| Gene Information | |
|---|---|
| Gene Name | KLKB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 638 |
| Protein Names | Plasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) (PKK) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain] |
| Target Name | plasma kallikrein messenger rna |
| Target Type | Clinical trial target |
| Gene Age | 950 ( ENSG00000164344 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P03952 |
| Gene Card | KLKB1 |
| Uniprot ID | P03952 |
| Pfam | PF00024; PF00089 |
| In ASD | no |
| Allosteric Prediction | yes (0.803740076) |
| Ortholog in Animals | Alpaca_ KLKB1 ( ortholog_one2one ) Dog_ KLKB1 ( ortholog_one2one ) GuineaPig_ KLKB1 ( ortholog_one2one ) Macaque_ KLKB1 ( ortholog_one2one ) Mouse_ Klkb1 ( ortholog_one2one ) Pig_ KLKB1 ( ortholog_one2one ) Rat_ Klkb1 ( ortholog_one2one ) Rabbit_ KLKB1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HGFAC, F7, C1R, KLK10, F9, F12, F10, CFI, CFD, PRSS55, PRSS51, C1S, C1RL, HP, HPR, F11 |
| Tissue | liver |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2ANW (X-ray 1.85A ) 2ANY (X-ray 1.40A ) 4OGX (X-ray 2.40A ) 4OGY (X-ray 2.10A ) 5F8T (X-ray 1.75A ) 5F8X (X-ray 1.55A ) 5F8Z (X-ray 1.50A ) 5TJX (X-ray 1.41A ) 6I44 (X-ray 1.36A ) 6O1G (X-ray 2.20A ) 6O1S (X-ray 1.70A ) 6T7P (X-ray 1.42A ) 7N7X (X-ray 2.10A ) |
| DBSNP | rs121964952 rs3733402 rs4253257 rs4253373 rs145640112 rs2278542 rs4253376 rs4253377 rs4253379 rs4253301 rs4253316 rs121964951 rs4253325 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
| click here to return to the previous page | |