| Gene Information | |
|---|---|
| Gene Name | PHOX2B |
| Organism | Homo sapiens (Human) |
| Gene Length | 314 |
| Protein Names | Paired mesoderm homeobox protein 2B (Neuroblastoma Phox) (NBPhox) (PHOX2B homeodomain protein) (Paired-like homeobox 2B) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000109132 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q99453 |
| Gene Card | PHOX2B |
| Uniprot ID | Q99453 |
| Pfam | PF00046 |
| In ASD | no |
| Allosteric Prediction | no (-0.815133466) |
| Ortholog in Animals | Alpaca_ PHOX2B ( ortholog_one2one ) GuineaPig_ PHOX2B ( ortholog_one2one ) Macaque_ PHOX2B ( ortholog_one2one ) Mouse_ Phox2b ( ortholog_one2one ) Pig_ PHOX2B ( ortholog_one2one ) Rat_ Phox2b ( ortholog_one2one ) |
| Ohnologs | PHOX2A |
| Paralogs | ARGFX, PAX7, PAX3, ALX4, PAX2, UNCX, RAX2, PAX8, DMBX1, DPRX, PAX5, ISX, ALX3, RHOXF2B, RHOXF2, GSC2, SEBOX, RAX, DRGX, ARX, RHOXF1, PITX3, PRRX1, SHOX, SHOX2, PRRX2, OTX2, PAX4, EVX1, PAX1, PITX2, PHOX2A, CRX, EVX2, ALX1, VSX2, MIXL1, DUXA, PAX6, OTP, HESX1, NOBOX, PROP1, PAX9, GSC, ESX1, DUXB, DUX4, PITX1, OTX1 |
| Tissue | NA |
| Tissue Specificity | Expressed in neuroblastoma, brain and adrenal gland. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7MJA (X-ray 1.69A ) |
| DBSNP | rs104893855 rs28939716 rs1733941453 rs104893856 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. |
| Mouse PG classification | NA |
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