| Gene Information | |
|---|---|
| Gene Name | PHOSPHO1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 267 |
| Protein Names | Phosphoethanolamine/phosphocholine phosphatase (EC 3.1.3.75) |
| Target Name | phosphoethanolamine/phosphocholine phosphatase |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000173868 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8TCT1 |
| Gene Card | PHOSPHO1 |
| Uniprot ID | Q8TCT1 |
| Pfam | PF06888 |
| In ASD | no |
| Allosteric Prediction | yes (0.147711089) |
| Ortholog in Animals | Alpaca_ PHOSPHO1 ( ortholog_one2one ) Dog_ PHOSPHO1 ( ortholog_one2one ) GuineaPig_ PHOSPHO1 ( ortholog_one2one ) Macaque_ PHOSPHO1 ( ortholog_one2one ) Mouse_ Phospho1 ( ortholog_one2one ) Rat_ Phospho1 ( ortholog_one2one ) Rabbit_ PHOSPHO1 ( ortholog_one2one ) |
| Ohnologs | PHOSPHO2 |
| Paralogs | PHOSPHO2 |
| Tissue | testis, whole.blood |
| Tissue Specificity | Expressed at sites of mineralization in bone and cartilage. Highly expressed in osteoblast cell line SaOS-2 which produces a mineralized matrix, but not in MG-63 cell line, which do not mineralize. {ECO:0000269|PubMed:15050893}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Extracellular vesicle {ECO:0000250|UniProtKB:Q8R2H9}. Note=Localizes to special class of extracellular vesicles, named matrix vesicles (MVs), which are released by osteogenic cells. {ECO:0000250|UniProtKB:Q8R2H9}. |
| Mouse PG classification | NA |
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