| Gene Information | |
|---|---|
| Gene Name | SRD5A2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 254 |
| Protein Names | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (EC 1.3.1.22) (5 alpha-SR2) (SR type 2) (Steroid 5-alpha-reductase 2) (S5AR 2) (Type II 5-alpha reductase) |
| Target Name | 3-oxo-5-alpha-steroid 4-dehydrogenase |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000277893 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P31213 |
| Gene Card | SRD5A2 |
| Uniprot ID | P31213 |
| Pfam | PF02544 |
| In ASD | no |
| Allosteric Prediction | yes (0.271373367) |
| Ortholog in Animals | Alpaca_ SRD5A2 ( ortholog_one2one ) Dog_ SRD5A2 ( ortholog_one2one ) GuineaPig_ SRD5A2 ( ortholog_one2one ) Macaque_ SRD5A2 ( ortholog_one2one ) Mouse_ Srd5a2 ( ortholog_one2one ) Pig_ SRD5A2 ( ortholog_one2one ) Rat_ Srd5a2 ( ortholog_one2one ) Rabbit_ SRD5A2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SRD5A1, TECRL, TECR |
| Tissue | liver, oviduct, prostate |
| Tissue Specificity | Expressed in high levels in the prostate and many other androgen-sensitive tissues. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7BW1 (X-ray 2.80A ) |
| DBSNP | rs61748120 rs61748122 rs9282858 rs61748123 rs121434245 rs1351269392 rs523349 rs28383048 rs121434246 rs1331249320 rs368386747 rs759561106 rs1057517829 rs121434247 rs61748125 rs61748126 rs121434250 rs121434253 rs756853742 rs9332961 rs767564684 rs121434252 rs9332963 rs9332963 rs9332964 rs121434249 rs121434251 rs1378704759 rs772283403 rs145712014 rs9332967 rs121434244 |
| Subcellular location [CC] | Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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