| Gene Information | |
|---|---|
| Gene Name | PCM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2024 |
| Protein Names | Pericentriolar material 1 protein (PCM-1) (hPCM-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000078674 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q15154 |
| Gene Card | PCM1 |
| Uniprot ID | Q15154 |
| Pfam | PF15717 |
| In ASD | no |
| Allosteric Prediction | no (-0.353739955) |
| Ortholog in Animals | Alpaca_ PCM1 ( ortholog_one2one ) Dog_ PCM1 ( ortholog_one2one ) GuineaPig_ PCM1 ( ortholog_one2one ) Macaque_ PCM1 ( ortholog_one2one ) Mouse_ Pcm1 ( ortholog_one2one ) Pig_ PCM1 ( ortholog_one2one ) Rat_ Pcm1 ( ortholog_one2one ) Rabbit_ PCM1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in blood, bone marrow, breast, lymph node, ovary and thyroid. {ECO:0000269|PubMed:10980597, ECO:0000269|PubMed:15184884, ECO:0000269|PubMed:16270321, ECO:0000269|PubMed:16424865}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6HYL (X-ray 1.56A ) 6HYM (X-ray 1.86A ) |
| DBSNP | rs412750 rs2285302 rs208753 rs34325017 rs17635381 rs7009117 rs17514547 rs34932823 rs370429 rs36113670 rs35789133 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8AV28}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:20719959, ECO:0000269|PubMed:30804208}. Cytoplasmic granule {ECO:0000269|PubMed:15107855}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:15107855, ECO:0000269|PubMed:20719959, ECO:0000269|PubMed:31789463, ECO:0000269|PubMed:34782749}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24121310}. Note=Recruitment to the centrosome requires microtubules and dynein. The majority of the protein dissociates from the centrosome during metaphase and subsequently localizes to the cleavage site in telophase. Displaced from centriolar satellites and centrosome in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, in a process that requires p38 MAP kinase signaling. |
| Mouse PG classification | NA |
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