Gene Information
Gene NameCHRNA7
OrganismHomo sapiens (Human)
Gene Length502
Protein NamesNeuronal acetylcholine receptor subunit alpha-7
Target Nameneuronal acetylcholine receptor alpha-7
Target TypeSuccessful target
Gene Age645 ( ENSG00000175344 )
3 ( ENSG00000274542 )
3 ( ENSG00000282088 )
Evolutionary StageEumetazoa
AlphaFoldDBP36544
Gene CardCHRNA7
Uniprot IDP36544
PfamPF02931; PF02932
In ASDyes
Allosteric Predictionyes (1.276722904)
Ortholog in AnimalsAlpaca_ CHRNA7 ( ortholog_one2one )
Dog_ CHRNA7 ( ortholog_one2many )
Macaque_ CHRNA7 ( ortholog_one2one )
Mouse_ Chrna7 ( ortholog_one2many )
Rat_ Chrna7 ( ortholog_one2many )
OhnologsNA
ParalogsCHRNB1, GABRR2, CHRNA6, CHRNB4, CHRNA4, GABRQ, HTR3E, CHRNA1, CHRNA3, GABRA5, GLRA2, HTR3B, GLRA1, GABRG3, GABRA2, GABRB3, GABRP, HTR3C, HTR3D, GABRG1, GABRD, GABRR1, CHRNA5, GABRA6, GABRA4, GLRA3, GABRE, CHRNE, GABRG2, CHRND, CHRNA2, CHRNA10, CHRNA9, GABRA3, HTR3A, ZACN, CHRNB3, CHRNB2, CHRNG, GABRR3, GABRB2, GABRB1, GABRA1, GLRB, CHRFAM7A
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.004323(Rat);0.066667(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2MAW  (NMR  -  )  5AFH  (X-ray  2.40A  )  5AFJ  (X-ray  2.20A  )  5AFK  (X-ray  2.38A  )  5AFL  (X-ray  2.38A  )  5AFM  (X-ray  2.85A  )  5AFN  (X-ray  2.15A  )  7EKI  (EM  3.18A  )  7EKP  (EM  2.85A  )  7EKT  (EM  3.02A  )  7KOO  (EM  3.00A  )  7KOQ  (EM  3.60A  )  7KOX  (EM  2.70A  )  7RPM  (NMR  -  ) 
DBSNP NA 
Subcellular location [CC]Postsynaptic cell membrane;
Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:27789755};
Multi-pass membrane protein {ECO:0000255}. Note=TMEM35A/NACHO promotes its trafficking to the cell membrane (PubMed:27789755). RIC3 promotes its trafficking to the cell membrane (By similarity). {ECO:0000250|UniProtKB:Q05941, ECO:0000269|PubMed:27789755}.
Mouse PG classificationNA
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