| Gene Information | |
|---|---|
| Gene Name | PHF2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1096 |
| Protein Names | Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000197724 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | O75151 |
| Gene Card | PHF2 |
| Uniprot ID | O75151 |
| Pfam | PF17811; PF02373; PF00628 |
| In ASD | no |
| Allosteric Prediction | yes (0.04884294) |
| Ortholog in Animals | Alpaca_ PHF2 ( ortholog_one2one ) Dog_ PHF2 ( ortholog_one2one ) GuineaPig_ PHF2 ( ortholog_one2one ) Macaque_ PHF2 ( ortholog_one2one ) Mouse_ Phf2 ( ortholog_one2one ) Pig_ PHF2 ( ortholog_one2one ) Rat_ Phf2 ( ortholog_one2one ) Rabbit_ PHF2 ( ortholog_one2one ) |
| Ohnologs | PHF8, KDM7A |
| Paralogs | KDM2A, KDM7A, PHF8, KDM2B |
| Tissue | NA |
| Tissue Specificity | Widely expressed, including in liver (at protein level). {ECO:0000269|PubMed:21532585}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3KQI (X-ray 1.78A ) 3PTR (X-ray 1.95A ) 3PU3 (X-ray 1.95A ) 3PU8 (X-ray 1.94A ) 3PUA (X-ray 1.89A ) 3PUS (X-ray 2.08A ) 7M10 (X-ray 1.15A ) |
| DBSNP | rs34279404 rs35236745 |
| Subcellular location [CC] | Nucleus, nucleolus {ECO:0000269|PubMed:20129925}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20813266}. |
| Mouse PG classification | NA |
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