| Gene Information | |
|---|---|
| Gene Name | GPR183 |
| Organism | Homo sapiens (Human) |
| Gene Length | 361 |
| Protein Names | G-protein coupled receptor 183 (Epstein-Barr virus-induced G-protein coupled receptor 2) (EBI2) (EBV-induced G-protein coupled receptor 2) (hEBI2) |
| Target Name | ebv-induced g-protein coupled receptor 2 |
| Target Type | Literature-reported target |
| Gene Age | 544 ( ENSG00000169508 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P32249 |
| Gene Card | GPR183 |
| Uniprot ID | P32249 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (0.793608121) |
| Ortholog in Animals | Alpaca_ GPR183 ( ortholog_one2one ) Dog_ GPR183 ( ortholog_one2one ) GuineaPig_ GPR183 ( ortholog_one2one ) Macaque_ GPR183 ( ortholog_one2one ) Mouse_ Gpr183 ( ortholog_one2one ) Pig_ GPR183 ( ortholog_one2one ) Rat_ Gpr183 ( ortholog_one2one ) Rabbit_ GPR183 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GPR174, GPR132, P2RY11, GPR141, GPR146, RXFP3, GPR151 |
| Tissue | NA |
| Tissue Specificity | Expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes (PubMed:16540462, PubMed:8383238). Also highly expressed in lung, heart and gastrointestinal tract, and weakly expressed in the urogenital system and brain (PubMed:16540462, PubMed:8383238). Expressed in astrocytes (PubMed:25297897). {ECO:0000269|PubMed:16540462, ECO:0000269|PubMed:25297897, ECO:0000269|PubMed:8383238}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 7TUY (EM 2.98A ) 7TUZ (EM 3.12A ) |
| DBSNP | rs1466524306 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:16540462, ECO:0000269|PubMed:18628402, ECO:0000269|PubMed:21673108, ECO:0000269|PubMed:22930711}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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