| Gene Information | |
|---|---|
| Gene Name | F2RL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 374 |
| Protein Names | Proteinase-activated receptor 3 (PAR-3) (Coagulation factor II receptor-like 2) (Thrombin receptor-like 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000164220 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O00254 |
| Gene Card | F2RL2 |
| Uniprot ID | O00254 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (1.220938069) |
| Ortholog in Animals | Alpaca_ F2RL2 ( ortholog_one2one ) Dog_ F2RL2 ( ortholog_one2one ) GuineaPig_ F2RL2 ( ortholog_one2one ) Macaque_ F2RL2 ( ortholog_one2one ) Mouse_ F2rl2 ( ortholog_one2one ) Pig_ F2RL2 ( ortholog_one2one ) Rat_ F2rl2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | F2RL3, F2RL1, F2R, P2RY8, GPR20, LPAR4, LPAR6, P2RY10, GPR35, GPR55, GPR18, GPR65, CYSLTR2, GPR17, GPR4, CYSLTR1 |
| Tissue | NA |
| Tissue Specificity | Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut. {ECO:0000269|PubMed:9614115}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.010990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2069649 rs2069700 rs2069683 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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