| Gene Information | |
|---|---|
| Gene Name | CHIT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 466 |
| Protein Names | Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1) |
| Target Name | chitotriosidase-1 |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000133063 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q13231 |
| Gene Card | CHIT1 |
| Uniprot ID | Q13231 |
| Pfam | PF01607; PF00704 |
| In ASD | no |
| Allosteric Prediction | yes (0.20838713) |
| Ortholog in Animals | Alpaca_ CHIT1 ( ortholog_one2one ) GuineaPig_ CHIT1 ( ortholog_one2one ) Macaque_ CHIT1 ( ortholog_one2one ) Mouse_ Chit1 ( ortholog_one2one ) Pig_ CHIT1 ( ortholog_one2one ) Rat_ Chit1 ( ortholog_one2one ) Rabbit_ CHIT1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CHIA, CHID1, CTBS, CHI3L1, OVGP1, CHI3L2 |
| Tissue | bone.marrow, lung, lymph.node |
| Tissue Specificity | Detected in spleen. Secreted by cultured macrophages. {ECO:0000269|PubMed:7836450}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1GUV (X-ray 2.35A ) 1HKI (X-ray 2.55A ) 1HKJ (X-ray 2.60A ) 1HKK (X-ray 1.85A ) 1HKM (X-ray 2.55A ) 1LG1 (X-ray 2.78A ) 1LG2 (X-ray 2.10A ) 1LQ0 (X-ray 2.20A ) 1WAW (X-ray 1.75A ) 1WB0 (X-ray 1.65A ) 4WJX (X-ray 1.00A ) 4WK9 (X-ray 1.10A ) 4WKA (X-ray 0.95A ) 4WKF (X-ray 1.10A ) 4WKH (X-ray 1.05A ) 5HBF (X-ray 1.95A ) 5NR8 (X-ray 1.35A ) 5NRA (X-ray 1.27A ) 5NRF (X-ray 1.45A ) 6JJR (X-ray 1.83A ) 6JK6 (X-ray 1.57A ) 6SO0 (NMR - ) 6ZE8 (X-ray 1.50A ) |
| DBSNP | rs35920428 rs137852607 rs2297950 rs12562058 rs1065761 |
| Subcellular location [CC] | Secreted. Lysosome. Note=A small proportion is lysosomal. |
| Mouse PG classification | NA |
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