| Gene Information | |
|---|---|
| Gene Name | PHAF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 422 |
| Protein Names | Phagosome assembly factor 1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000125149 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BSU1 |
| Gene Card | PHAF1 |
| Uniprot ID | Q9BSU1 |
| Pfam | PF03676 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | Alpaca_ PHAF1 ( ortholog_one2one ) Dog_ PHAF1 ( ortholog_one2one ) GuineaPig_ PHAF1 ( ortholog_one2one ) Macaque_ PHAF1 ( ortholog_one2one ) Mouse_ Phaf1 ( ortholog_one2one ) Pig_ PHAF1 ( ortholog_one2one ) Rat_ RGD621098 ( ortholog_one2one ) Rabbit_ PHAF1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TBC1D32 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:33499712}. Preautophagosomal structure {ECO:0000269|PubMed:33499712}. Note=The BCAS3:PHAF1 complex is recruited to the preautophagosomal structures adjacent to the damaged mitochondria upon mitophagy in a PRKN-PINK1 dependent manner. {ECO:0000269|PubMed:33499712}. |
| Mouse PG classification | NA |
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