| Gene Information | |
|---|---|
| Gene Name | PRC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 620 |
| Protein Names | Protein regulator of cytokinesis 1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000198901 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O43663 |
| Gene Card | PRC1 |
| Uniprot ID | O43663 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.1046024) |
| Ortholog in Animals | Alpaca_ PRC1 ( ortholog_one2one ) Dog_ PRC1 ( ortholog_one2one ) GuineaPig_ PRC1 ( ortholog_one2one ) Macaque_ PRC1 ( ortholog_one2one ) Mouse_ Prc1 ( ortholog_one2one ) Pig_ PRC1 ( ortholog_one2one ) Rat_ Prc1 ( ortholog_one2one ) Rabbit_ PRC1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | brain, testis |
| Tissue Specificity | Overexpressed in bladder cancer cells (PubMed:17409436). {ECO:0000269|PubMed:17409436}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.007143(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3NRX (X-ray 1.75A ) 3NRY (X-ray 2.00A ) 4L3I (X-ray 3.60A ) 4L6Y (X-ray 3.30A ) 5KMG (EM 3.50A ) 7VBG (NMR - ) |
| DBSNP | rs7172758 rs12911192 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:17409436}. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105}. Midbody {ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:17409436}. Chromosome {ECO:0000269|PubMed:15297875}. Note=Colocalized with KIF20B in the nucleus of bladder carcinoma cells at the interphase. Colocalized with KIF20B in bladder carcinoma cells at prophase, metaphase, early anaphase, at the midzone in late anaphase and at the contractile ring in telophase (PubMed:17409436). Predominantly localized to the nucleus of interphase cells. During mitosis becomes associated with the mitotic spindle poles and localizes with the cell midbody during cytokinesis. Co-localizes with PRC1 in early mitosis and at the spindle midzone from anaphase B to telophase (PubMed:15297875, PubMed:15625105). {ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:17409436}. |
| Mouse PG classification | NA |
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