| Gene Information | |
|---|---|
| Gene Name | NFATC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 925 |
| Protein Names | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000101096 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q13469 |
| Gene Card | NFATC2 |
| Uniprot ID | Q13469 |
| Pfam | PF16179; PF00554 |
| In ASD | no |
| Allosteric Prediction | yes (0.342734033) |
| Ortholog in Animals | Alpaca_ NFATC2 ( ortholog_one2one ) Dog_ NFATC2 ( ortholog_one2one ) GuineaPig_ NFATC2 ( ortholog_one2one ) Macaque_ NFATC2 ( ortholog_one2one ) Mouse_ Nfatc2 ( ortholog_one2one ) Pig_ NFATC2 ( ortholog_one2one ) Rat_ Nfatc2 ( ortholog_one2one ) Rabbit_ NFATC2 ( ortholog_one2one ) |
| Ohnologs | NFATC3, NFATC4, NFATC1 |
| Paralogs | NFATC3, NFATC4, NFAT5, NFATC1 |
| Tissue | NA |
| Tissue Specificity | Expressed in thymus, spleen, heart, testis, brain, placenta, muscle and pancreas. Isoform 1 is highly expressed in the small intestine, heart, testis, prostate, thymus, placenta and thyroid. Isoform 3 is highly expressed in stomach, uterus, placenta, trachea and thyroid. {ECO:0000269|PubMed:8668213}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.020094(Mouse);0.002990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1A02 (X-ray 2.70A ) 1OWR (X-ray 3.00A ) 1P7H (X-ray 2.60A ) 1PZU (X-ray 3.10A ) 1S9K (X-ray 3.10A ) 2AS5 (X-ray 2.70A ) 2O93 (X-ray 3.05A ) 3QRF (X-ray 2.80A ) |
| DBSNP | rs12479626 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. |
| Mouse PG classification | NA |
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