| Gene Information | |
|---|---|
| Gene Name | DIS3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 958 |
| Protein Names | Exosome complex exonuclease RRP44 (EC 3.1.13.-) (EC 3.1.26.-) (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000083520 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q9Y2L1 |
| Gene Card | DIS3 |
| Uniprot ID | Q9Y2L1 |
| Pfam | PF17849; PF13638; PF00773; PF17216; PF17215 |
| In ASD | yes |
| Allosteric Prediction | yes (0.327202238) |
| Ortholog in Animals | Alpaca_ DIS3 ( ortholog_one2one ) Dog_ DIS3 ( ortholog_one2one ) GuineaPig_ DIS3 ( ortholog_one2one ) Macaque_ DIS3 ( ortholog_one2one ) Mouse_ Dis3 ( ortholog_one2one ) Pig_ DIS3 ( ortholog_one2one ) Rat_ Dis3 ( ortholog_one2one ) Rabbit_ DIS3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DIS3L, DIS3L2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. |
| Pharmacological Animal Models | 0.028380(Chimpanzee);0.030822(Mouse);0.002657(Rat);0.044000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 6D6Q (EM 3.45A ) 6D6R (EM 3.45A ) 6H25 (EM 3.80A ) |
| DBSNP | rs4883918 rs7332388 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:20531386}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. Nucleus, nucleoplasm {ECO:0000269|PubMed:20531389}. Nucleus {ECO:0000269|PubMed:20531386}. Note=Predominantly located in the nucleus (PubMed:20531386). According to PubMed:12429849, found in the nucleolus (PubMed:12429849). According to PubMed:20531386, excluded from nucleolus supporting the existence of a nucleolar RNA exosome complex devoid of DIS3 (PubMed:20531386). {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:20531386}. |
| Mouse PG classification | NA |
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