Gene Information
Gene NameSLC15A4
OrganismHomo sapiens (Human)
Gene Length577
Protein NamesSolute carrier family 15 member 4 (Peptide transporter 4) (Peptide/histidine transporter 1) (hPHT1)
Target Namesolute carrier family 15 member 4
Target TypeLiterature-reported target
Gene Age645 ( ENSG00000139370 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ8N697
Gene CardSLC15A4
Uniprot IDQ8N697
PfamPF00854
In ASDno
Allosteric Predictionno (-0.12218448)
Ortholog in AnimalsAlpaca_ SLC15A4 ( ortholog_one2one )
Dog_ SLC15A4 ( ortholog_one2one )
GuineaPig_ SLC15A4 ( ortholog_one2one )
Macaque_ SLC15A4 ( ortholog_one2one )
Mouse_ Slc15a4 ( ortholog_one2one )
Pig_ SLC15A4 ( ortholog_one2one )
Rat_ Slc15a4 ( ortholog_one2one )
Rabbit_ SLC15A4 ( ortholog_one2one )
OhnologsSLC15A3
ParalogsSLC15A1, SLC15A5, SLC15A3, SLC15A2
TissueNA
Tissue SpecificityHighly expressed in skeletal muscle. Moderately expressed in kidney, liver, and heart. Weakly expressed in colon and brain. Expressed in low levels throughout the gastrointestinal tract and in Caco-2 cells. Expressed in retinal fragment epithelium (RPE) and neural retina. Expressed in small intestine, stomach, duodenum, jejunum, ileum and colon. {ECO:0000269|PubMed:11741232, ECO:0000269|PubMed:11741260, ECO:0000269|PubMed:16289537}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs33990080 
Subcellular location [CC]Lysosome membrane {ECO:0000269|PubMed:25238095, ECO:0000269|PubMed:29224352, ECO:0000269|PubMed:32433612};
Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:32433612};
Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q91W98};
Multi-pass membrane protein {ECO:0000255}.
Mouse PG classificationNA
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