| Gene Information | |
|---|---|
| Gene Name | PGR |
| Organism | Homo sapiens (Human) |
| Gene Length | 933 |
| Protein Names | Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) |
| Target Name | progesterone receptor |
| Target Type | Successful target |
| Gene Age | 950 ( ENSG00000082175 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P06401 |
| Gene Card | PGR |
| Uniprot ID | P06401 |
| Pfam | PF00104; PF02161; PF00105 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000111811) |
| Ortholog in Animals | Alpaca_ PGR ( ortholog_one2one ) Dog_ PGR ( ortholog_one2one ) Macaque_ PGR ( ortholog_one2one ) Mouse_ Pgr ( ortholog_one2one ) Pig_ PGR ( ortholog_one2one ) Rat_ Pgr ( ortholog_one2one ) Rabbit_ PGR ( ortholog_one2one ) |
| Ohnologs | AR, ESRRA, ESR1, NR3C1, NR3C2 |
| Paralogs | ESRRG, ESRRB, NR3C1, ESRRA, ESR1, AR, ESR2, NR3C2 |
| Tissue | endometrium, oviduct, smooth.muscle, cervix, uterus, ectocervix, endocervix |
| Tissue Specificity | In reproductive tissues the expression of isoform A and isoform B varies as a consequence of developmental and hormonal status. Isoform A and isoform B are expressed in comparable levels in uterine glandular epithelium during the proliferative phase of the menstrual cycle. Expression of isoform B but not of isoform A persists in the glands during mid-secretory phase. In the stroma, isoform A is the predominant form throughout the cycle. Heterogeneous isoform expression between the glands of the endometrium basalis and functionalis is implying region-specific responses to hormonal stimuli. {ECO:0000269|PubMed:11041221}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.038095(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1A28 (X-ray 1.80A ) 1E3K (X-ray 2.80A ) 1SQN (X-ray 1.45A ) 1SR7 (X-ray 1.46A ) 1ZUC (X-ray 2.00A ) 2C7A (X-ray 2.50A ) 2OVH (X-ray 2.00A ) 2OVM (X-ray 2.60A ) 2W8Y (X-ray 1.80A ) 3D90 (X-ray 2.26A ) 3G8O (X-ray 1.90A ) 3HQ5 (X-ray 2.10A ) 3KBA (X-ray 2.00A ) 3ZR7 (X-ray 1.65A ) 3ZRA (X-ray 1.90A ) 3ZRB (X-ray 1.80A ) 4A2J (X-ray 2.00A ) 4APU (X-ray 1.90A ) 4OAR (X-ray 2.41A ) 5CC0 (X-ray 2.40A ) |
| DBSNP | rs11571143 rs11571144 rs11571145 rs11571146 rs3740753 rs11571147 rs11571150 rs11571151 rs11571152 rs2020874 rs11571222 rs1042838 rs2020880 |
| Subcellular location [CC] | Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both hormone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases.; [Isoform A]: Nucleus. Cytoplasm. Note=Mainly nuclear.; [Isoform 4]: Mitochondrion outer membrane {ECO:0000269|PubMed:23518922}. |
| Mouse PG classification | NA |
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