| Gene Information | |
|---|---|
| Gene Name | SPHKAP |
| Organism | Homo sapiens (Human) |
| Gene Length | 1700 |
| Protein Names | A-kinase anchor protein SPHKAP (SPHK1-interactor and AKAP domain-containing protein) (Sphingosine kinase type 1-interacting protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000153820 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q2M3C7 |
| Gene Card | SPHKAP |
| Uniprot ID | Q2M3C7 |
| Pfam | PF05716 |
| In ASD | no |
| Allosteric Prediction | no (-0.529310346) |
| Ortholog in Animals | Alpaca_ SPHKAP ( ortholog_one2one ) Dog_ SPHKAP ( ortholog_one2one ) GuineaPig_ SPHKAP ( ortholog_one2one ) Macaque_ SPHKAP ( ortholog_one2one ) Mouse_ Sphkap ( ortholog_one2one ) Pig_ SPHKAP ( ortholog_one2one ) Rat_ Sphkap ( ortholog_one2one ) Rabbit_ SPHKAP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | AKAP11, AKAP4, AKAP3 |
| Tissue | brain, heart, cerebral.cortex, cerebellum, ovary, cerebellar.hemisphere |
| Tissue Specificity | Highly expressed in heart. Both isoforms abundantly expressed in ventricle. Also expressed in spleen, ovary and brain. {ECO:0000269|PubMed:12080051, ECO:0000269|PubMed:20394097}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs4283414 rs3811514 rs3811515 rs3828161 rs16824283 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12080051, ECO:0000269|PubMed:20394097}. Note=Colocalizes with SPHK1 in the cytoplasm. |
| Mouse PG classification | NA |
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