| Gene Information | |
|---|---|
| Gene Name | PGK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 417 |
| Protein Names | Phosphoglycerate kinase 1 (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2) |
| Target Name | phosphoglycerate kinase 1 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000102144 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P00558 |
| Gene Card | PGK1 |
| Uniprot ID | P00558 |
| Pfam | PF00162 |
| In ASD | no |
| Allosteric Prediction | yes (1.242095231) |
| Ortholog in Animals | Alpaca_ PGK1 ( ortholog_one2one ) Dog_ PGK1 ( ortholog_one2one ) GuineaPig_ PGK1 ( ortholog_one2one ) Mouse_ Pgk1 ( ortholog_one2one ) Pig_ PGK1 ( ortholog_one2one ) Rat_ RGD1560402 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | PGK2 |
| Tissue | NA |
| Tissue Specificity | Mainly expressed in spermatogonia. Localized on the principle piece in the sperm (at protein level). Expression significantly decreased in the testis of elderly men. {ECO:0000269|PubMed:26677959}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.011765(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2WZB (X-ray 1.47A ) 2WZC (X-ray 1.50A ) 2WZD (X-ray 1.56A ) 2X13 (X-ray 1.74A ) 2X14 (X-ray 1.90A ) 2X15 (X-ray 2.10A ) 2XE6 (X-ray 1.74A ) 2XE7 (X-ray 2.20A ) 2XE8 (X-ray 1.79A ) 2Y3I (X-ray 2.90A ) 2YBE (X-ray 2.00A ) 2ZGV (X-ray 2.00A ) 3C39 (X-ray 1.85A ) 3C3A (X-ray 2.30A ) 3C3B (X-ray 1.80A ) 3C3C (X-ray 2.40A ) 3ZOZ (X-ray 1.95A ) 4AXX (X-ray 1.74A ) 4O33 (X-ray 2.10A ) 5M1R (X-ray 1.64A ) 5M3U (X-ray 1.81A ) 5M6Z (X-ray 1.67A ) 5MXM (X-ray 2.05A ) 5NP8 (X-ray 1.90A ) 5O7D (X-ray 1.84A ) |
| DBSNP | rs137852531 rs137852532 rs137852538 rs137852529 rs431905501 rs137852528 rs137852535 rs137852533 rs137852530 |
| Subcellular location [CC] | Cytoplasm. |
| Mouse PG classification | NA |
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