| Gene Information | |
|---|---|
| Gene Name | PGFT |
| Organism | Homo sapiens (Human) |
| Gene Length | 1010 |
| Protein Names | Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P22102 |
| Gene Card | GART |
| Uniprot ID | P22102 |
| Pfam | PF00586; PF02769; PF00551; PF01071; PF02843; PF02844 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.009839(Chimpanzee);0.035650(Mouse);0.003583(Rat);0.059259(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1MEJ (X-ray 2.00A ) 1MEN (X-ray 2.23A ) 1MEO (X-ray 1.72A ) 1NJS (X-ray 1.98A ) 1RBM (X-ray 2.30A ) 1RBQ (X-ray 2.10A ) 1RBY (X-ray 2.10A ) 1RBZ (X-ray 2.10A ) 1RC0 (X-ray 2.05A ) 1RC1 (X-ray 2.25A ) 1ZLX (X-ray 2.20A ) 1ZLY (X-ray 2.07A ) 2QK4 (X-ray 2.45A ) 2V9Y (X-ray 2.10A ) 4EW1 (X-ray 1.52A ) 4EW2 (X-ray 1.60A ) 4EW3 (X-ray 1.70A ) 4ZYT (X-ray 1.70A ) 4ZYU (X-ray 1.95A ) 4ZYV (X-ray 2.05A ) 4ZYW (X-ray 2.05A ) 4ZYX (X-ray 1.65A ) 4ZYY (X-ray 1.85A ) 4ZYZ (X-ray 1.60A ) 4ZZ0 (X-ray 1.65A ) 4ZZ1 (X-ray 1.35A ) 4ZZ2 (X-ray 1.45A ) 4ZZ3 (X-ray 2.50A ) 5J9F (X-ray 2.10A ) 7JG0 (X-ray 1.98A ) 7JG3 (X-ray 2.09A ) 7JG4 (X-ray 2.46A ) |
| DBSNP | rs1804387 rs8788 rs35927582 rs34588874 rs8971 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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