Gene Information
Gene NameSLC46A1
OrganismHomo sapiens (Human)
Gene Length459
Protein NamesProton-coupled folate transporter (HsPCFT) (hPCFT) (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1)
Target Nameproton-coupled folate transporter
Target TypeSuccessful target
Gene Age950 ( ENSG00000076351 )
Evolutionary StageOpisthokonta
AlphaFoldDBQ96NT5
Gene CardSLC46A1
Uniprot IDQ96NT5
PfamPF07690
In ASDno
Allosteric Predictionyes (0.012973672)
Ortholog in AnimalsAlpaca_ SLC46A1 ( ortholog_one2one )
Dog_ SLC46A1 ( ortholog_one2one )
GuineaPig_ SLC46A1 ( ortholog_one2one )
Macaque_ SLC46A1 ( ortholog_one2one )
Mouse_ Slc46a1 ( ortholog_one2one )
Pig_ SLC46A1 ( ortholog_one2one )
Rat_ Slc46a1 ( ortholog_one2one )
Rabbit_ SLC46A1 ( ortholog_one2one )
OhnologsSLC46A2
ParalogsSLC46A3, SLC46A2
Tissueduodenum
Tissue SpecificityExpressed at highest level in the upper half of the small intestine (duodenum and jejunum), expression decreases downwardly in the subsequent quarter and is undetectable in the last quarter (the lowest ileum) (PubMed:17129779, PubMed:19762432). Also expressed in kidney, liver, placenta, spleen, retina and retinal pigment epithelium (PubMed:17129779, PubMed:17335806). Lower levels found in testis (PubMed:17129779). Very low levels in brain, lung, stomach, heart and muscle (PubMed:17129779). {ECO:0000269|PubMed:17129779, ECO:0000269|PubMed:17335806, ECO:0000269|PubMed:19762432}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs80338770  rs80338770  rs80338771  rs281875210  rs34552966  rs80338772  rs281875208  rs281875209  rs281875211  rs80338773  rs80338774 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:17156779, ECO:0000269|PubMed:17446347, ECO:0000269|PubMed:18405659, ECO:0000269|PubMed:23601781, ECO:0000269|PubMed:25053408, ECO:0000269|PubMed:25504888, ECO:0000269|PubMed:29344585, ECO:0000269|PubMed:30858177, ECO:0000269|PubMed:34619546};
Multi-pass membrane protein {ECO:0000269|PubMed:25053408}. Apical cell membrane {ECO:0000269|PubMed:16143108, ECO:0000269|PubMed:17129779, ECO:0000269|PubMed:17475902};
Multi-pass membrane protein {ECO:0000269|PubMed:25053408}. Basolateral cell membrane {ECO:0000269|PubMed:19074442};
Multi-pass membrane protein {ECO:0000269|PubMed:25053408}. Endosome membrane {ECO:0000305|PubMed:19074442};
Multi-pass membrane protein {ECO:0000269|PubMed:25053408}. Cytoplasm {ECO:0000250|UniProtKB:Q6PEM8}. Note=Localizes to the apical membrane of intestinal cells in iron-deficient cells, while it resides in the cytoplasm in iron-replete cells (By similarity). Localizes to the basolateral membrane of choroid plexus (PubMed:19074442). {ECO:0000250|UniProtKB:Q6PEM8, ECO:0000269|PubMed:19074442}.
Mouse PG classificationLPG
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