| Gene Information | |
|---|---|
| Gene Name | PGF |
| Organism | Homo sapiens (Human) |
| Gene Length | 221 |
| Protein Names | Placenta growth factor (PlGF) |
| Target Name | placenta growth factor |
| Target Type | Successful target |
| Gene Age | 454 ( ENSG00000119630 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P49763 |
| Gene Card | PGF |
| Uniprot ID | P49763 |
| Pfam | PF00341 |
| In ASD | no |
| Allosteric Prediction | yes (0.103364604) |
| Ortholog in Animals | Alpaca_ PGF ( ortholog_one2one ) GuineaPig_ PGF ( ortholog_one2one ) Macaque_ PGF ( ortholog_one2one ) Mouse_ Pgf ( ortholog_one2one ) Pig_ PGF ( ortholog_one2one ) Rat_ Pgf ( ortholog_one2one ) Rabbit_ PGF ( ortholog_one2one ) |
| Ohnologs | VEGFB |
| Paralogs | VEGFD, VEGFC, VEGFA, VEGFB |
| Tissue | placenta, thyroid |
| Tissue Specificity | While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas. |
| Pharmacological Animal Models | 0.087880(Chimpanzee);NULL(Mouse);0.004323(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1FZV (X-ray 2.00A ) 1RV6 (X-ray 2.45A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted. Note=The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin. |
| Mouse PG classification | NA |
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