| Gene Information | |
|---|---|
| Gene Name | PGAR |
| Organism | Homo sapiens (Human) |
| Gene Length | 406 |
| Protein Names | Angiopoietin-related protein 4 (Angiopoietin-like protein 4) (Hepatic fibrinogen/angiopoietin-related protein) (HFARP) [Cleaved into: ANGPTL4 N-terminal chain; ANGPTL4 C-terminal chain] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9BY76 |
| Gene Card | ANGPTL4 |
| Uniprot ID | Q9BY76 |
| Pfam | PF00147 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in blood plasma (at protein level) (PubMed:29899519). Detected in liver (PubMed:10698685). Detected in white fat tissue and placenta (PubMed:10866690). Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney. {ECO:0000269|PubMed:10698685, ECO:0000269|PubMed:10866690, ECO:0000269|PubMed:12015030, ECO:0000269|PubMed:29899519}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6EUB (X-ray 2.30A ) 6U0A (X-ray 2.11A ) 6U1U (X-ray 1.75A ) 6U73 (X-ray 2.38A ) |
| DBSNP | rs761583091 rs116843064 rs186754194 rs538554190 rs141831018 rs568624939 rs140640857 rs1008363865 rs77938377 rs1192364228 rs201026877 rs768374046 rs376328756 rs1044250 rs35061979 rs150000287 rs775667046 rs751249880 rs139998264 rs140744493 rs780121474 rs1033145581 rs755737249 rs755737249 rs779488814 rs146942305 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:10698685, ECO:0000269|PubMed:14583458, ECO:0000269|PubMed:17068295, ECO:0000269|PubMed:19270337, ECO:0000269|PubMed:21398697, ECO:0000269|PubMed:29899519}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17068295, ECO:0000269|PubMed:21398697}. Note=The unprocessed form interacts with the extracellular matrix (PubMed:17068295, PubMed:21398697). This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 (Probable). {ECO:0000269|PubMed:17068295, ECO:0000269|PubMed:21398697, ECO:0000305|PubMed:17068295}. |
| Mouse PG classification | NA |
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