| Gene Information | |
|---|---|
| Gene Name | PEG3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1588 |
| Protein Names | Paternally-expressed gene 3 protein (Zinc finger and SCAN domain-containing protein 24) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 132 ( ENSG00000198300 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q9GZU2 |
| Gene Card | PEG3 |
| Uniprot ID | Q9GZU2 |
| Pfam | PF02023; PF00096 |
| In ASD | no |
| Allosteric Prediction | no (-0.715433058) |
| Ortholog in Animals | Alpaca_ PEG3 ( ortholog_one2one ) Dog_ PEG3 ( ortholog_one2one ) Macaque_ PEG3 ( ortholog_one2one ) Mouse_ Peg3 ( ortholog_one2one ) Pig_ PEG3 ( ortholog_one2one ) Rat_ Peg3 ( ortholog_one2one ) Rabbit_ PEG3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ZSCAN32, ZNF641, ZNF274, ZNF131, ZSCAN5C, ZSCAN5A, ZNF518A, SCAND1, ZSCAN29, ZSCAN1, ZNF202, ZSCAN18, ZNF444, PLAG1, ZNF18, PLAGL1, ZKSCAN2, ZSCAN5B, ZNF576, PLAGL2, ZNF496, REST, ZNF174, OVOL1, OVOL2, ZNF446, OVOL3, ZNF770, ZNF518B |
| Tissue | NA |
| Tissue Specificity | Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and uterus. In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian stroma including the thecal layers around the follicles. Expression is highly repressed in glioma cell lines. {ECO:0000269|PubMed:11260267, ECO:0000269|PubMed:11331620, ECO:0000269|PubMed:9149948}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4BHX (X-ray 1.95A ) |
| DBSNP | rs2191432 rs754473044 rs36016896 rs7251798 rs35851866 rs10412932 rs34831553 rs34051133 rs34051133 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}. Cytoplasm {ECO:0000250}. |
| Mouse PG classification | NA |
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