| Gene Information | |
|---|---|
| Gene Name | PFKFB3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 520 |
| Protein Names | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (6PF-2-K/Fru-2,6-P2ase 3) (PFK/FBPase 3) (6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme) (Renal carcinoma antigen NY-REN-56) (iPFK-2) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] |
| Target Name | renal carcinoma antigen ny-ren-56 |
| Target Type | Clinical trial target |
| Gene Age | 1064 ( ENSG00000170525 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q16875 |
| Gene Card | PFKFB3 |
| Uniprot ID | Q16875 |
| Pfam | PF01591; PF00300 |
| In ASD | yes |
| Allosteric Prediction | yes (1.057601715) |
| Ortholog in Animals | Alpaca_ PFKFB3 ( ortholog_one2one ) Dog_ PFKFB3 ( ortholog_one2one ) GuineaPig_ PFKFB3 ( ortholog_one2one ) Macaque_ PFKFB3 ( ortholog_one2one ) Mouse_ Pfkfb3 ( ortholog_one2one ) Pig_ PFKFB3 ( ortholog_one2one ) Rat_ Pfkfb3 ( ortholog_one2one ) Rabbit_ PFKFB3 ( ortholog_one2one ) |
| Ohnologs | PFKFB1, PFKFB4, PFKFB2 |
| Paralogs | PFKFB2, PFKFB4, PFKFB1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2AXN (X-ray 2.10A ) 2DWO (X-ray 2.25A ) 2DWP (X-ray 2.70A ) 2I1V (X-ray 2.50A ) 3QPU (X-ray 2.30A ) 3QPV (X-ray 2.50A ) 3QPW (X-ray 2.25A ) 4D4J (X-ray 3.00A ) 4D4K (X-ray 3.24A ) 4D4L (X-ray 3.16A ) 4D4M (X-ray 2.32A ) 4MA4 (X-ray 2.23A ) 5AJV (X-ray 3.01A ) 5AJW (X-ray 2.50A ) 5AJX (X-ray 2.58A ) 5AJY (X-ray 2.37A ) 5AJZ (X-ray 2.35A ) 5AK0 (X-ray 2.03A ) 6ETJ (X-ray 2.51A ) 6HVH (X-ray 2.36A ) 6HVI (X-ray 1.96A ) 6HVJ (X-ray 2.28A ) 6IBX (X-ray 2.11A ) 6IBY (X-ray 2.51A ) 6IBZ (X-ray 2.44A ) 6IC0 (X-ray 2.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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