| Gene Information | |
|---|---|
| Gene Name | TMPRSS11A |
| Organism | Homo sapiens (Human) |
| Gene Length | 418 |
| Protein Names | Transmembrane protease serine 11A (EC 3.4.21.-) (Airway trypsin-like protease 1) (Epidermal type-II transmembrane serine protease) (Esophageal cancer-susceptibility gene 1 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000187054 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q6ZMR5 |
| Gene Card | TMPRSS11A |
| Uniprot ID | Q6ZMR5 |
| Pfam | PF01390; PF00089 |
| In ASD | no |
| Allosteric Prediction | no (-1.002386101) |
| Ortholog in Animals | Alpaca_ TMPRSS11A ( ortholog_one2one ) Dog_ TMPRSS11A ( ortholog_one2one ) GuineaPig_ TMPRSS11A ( ortholog_one2one ) Macaque_ TMPRSS11A ( ortholog_one2one ) Mouse_ Tmprss11a ( ortholog_one2one ) Pig_ TMPRSS11A ( ortholog_one2one ) Rat_ Tmprss11a ( ortholog_one2one ) Rabbit_ TMPRSS11A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TMPRSS15, TMPRSS6, HPN, TMPRSS11E, ST14, TMPRSS3, TMPRSS13, TMPRSS11D, TMPRSS2, PRSS22, TMPRSS7, TMPRSS11B, TMPRSS9, TMPRSS5, PRSS21, PRSS41, TMPRSS11F |
| Tissue | esophagus, esophagus.mucosa, vagina |
| Tissue Specificity | Expressed in esophagus, liver, colon and lung. Down-regulated in esophagus cancers. {ECO:0000269|PubMed:10920976}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs353163 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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