Gene Information
Gene NameNEURL1
OrganismHomo sapiens (Human)
Gene Length574
Protein NamesE3 ubiquitin-protein ligase NEURL1 (EC 2.3.2.27) (Neuralized-like protein 1A) (h-neu) (h-neuralized 1) (RING finger protein 67) (RING-type E3 ubiquitin transferase NEURL1)
Target NameNA
Target TypeNA
Gene Age454 ( ENSG00000107954 )
Evolutionary StageEumetazoa
AlphaFoldDBO76050
Gene CardNEURL1
Uniprot IDO76050
PfamPF07177
In ASDno
Allosteric Predictionno (-0.753681225)
Ortholog in AnimalsAlpaca_ NEURL1 ( ortholog_one2one )
Dog_ NEURL1 ( ortholog_one2one )
GuineaPig_ NEURL1 ( ortholog_one2one )
Macaque_ NEURL1 ( ortholog_one2one )
Mouse_ Neurl1a ( ortholog_one2one )
Pig_ NEURL1 ( ortholog_one2one )
Rat_ Neurl1 ( ortholog_one2one )
Rabbit_ NEURL1 ( ortholog_one2one )
OhnologsNEURL1B
ParalogsNEURL1B, NEURL3, NEURL4
TissueNA
Tissue SpecificityExpressed in brain, testis, pituitary gland, pancreas and bone marrow. Also poorly expressed in malignant astrocytomas and several neuroectodermal tumor cell lines. Weakly expressed in medulloblastoma (MB) compared with normal cerebellar tissues. {ECO:0000269|PubMed:11585928, ECO:0000269|PubMed:9519875}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC]Cytoplasm, perinuclear region {ECO:0000269|PubMed:11585928, ECO:0000269|PubMed:20847082}. Cell membrane {ECO:0000250};
Peripheral membrane protein {ECO:0000250}. Perikaryon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Postsynaptic density {ECO:0000250}. Note=Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons (By similarity). Colocalized with JAG1 at the cell surface. {ECO:0000250}.
Mouse PG classificationNA
click here to return to the previous page