| Gene Information | |
|---|---|
| Gene Name | PCSK6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 969 |
| Protein Names | Proprotein convertase subtilisin/kexin type 6 (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin-like proprotein convertase 4) (SPC4) (Subtilisin/kexin-like protease PACE4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000140479 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P29122 |
| Gene Card | PCSK6 |
| Uniprot ID | P29122 |
| Pfam | PF14843; PF01483; PF00082; PF08686; PF16470 |
| In ASD | no |
| Allosteric Prediction | no (-0.464888649) |
| Ortholog in Animals | Alpaca_ PCSK6 ( ortholog_one2one ) Dog_ PCSK6 ( ortholog_one2one ) GuineaPig_ PCSK6 ( ortholog_one2one ) Macaque_ PCSK6 ( ortholog_one2one ) Mouse_ Pcsk6 ( ortholog_one2one ) Pig_ PCSK6 ( ortholog_one2one ) Rat_ Pcsk6 ( ortholog_one2one ) Rabbit_ PCSK6 ( ortholog_one2one ) |
| Ohnologs | PCSK4, PCSK1 |
| Paralogs | PCSK1, TPP2, MBTPS1, PCSK7, PCSK5, PCSK9, PCSK4, FURIN, PCSK2 |
| Tissue | liver, spleen |
| Tissue Specificity | Each PACE4 isoform exhibits a unique restricted distribution. Isoform PACE4A-I is expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, but at comparatively higher levels in the liver. Isoform PACE4A-II is at least expressed in placenta. Isoform PACE4B was only found in the embryonic kidney cell line from which it was isolated. Isoform PACE4C and isoform PACE4D are expressed in placenta. Isoform PACE4E-I is expressed in cerebellum, placenta and pituitary. Isoform PACE4E-II is at least present in cerebellum. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs1058260 |
| Subcellular location [CC] | [Isoform PACE4A-I]: Secreted.; [Isoform PACE4A-II]: Secreted.; [Isoform PACE4C]: Endoplasmic reticulum. Note=Not secreted, remains probably in zymogen form in endoplasmic reticulum.; [Isoform PACE4CS]: Endoplasmic reticulum. Note=Not secreted, remains probably in zymogen form in endoplasmic reticulum.; [Isoform PACE4E-I]: Endomembrane system; Peripheral membrane protein. Note=Retained intracellularly probably through a hydrophobic cluster in their C-terminus.; [Isoform PACE4E-II]: Endomembrane system; Peripheral membrane protein. Note=Retained intracellularly probably through a hydrophobic cluster in their C-terminus.; [Isoform PACE4B]: Secreted. |
| Mouse PG classification | NA |
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