| Gene Information | |
|---|---|
| Gene Name | PF4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 101 |
| Protein Names | Platelet factor 4 (PF-4) (C-X-C motif chemokine 4) (Iroplact) (Oncostatin-A) [Cleaved into: Platelet factor 4, short form (Endothelial cell growth inhibitor)] |
| Target Name | platelet factor 4 |
| Target Type | Clinical trial target |
| Gene Age | 55 ( ENSG00000163737 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P02776 |
| Gene Card | PF4 |
| Uniprot ID | P02776 |
| Pfam | PF00048 |
| In ASD | no |
| Allosteric Prediction | yes (0.172563905) |
| Ortholog in Animals | Alpaca_ PF4 ( ortholog_one2one ) Macaque_ PF4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PF4V1, CXCL8, CXCL5, CXCL2, CXCL3, CXCL10, CXCL9, CXCL1, CXCL13, CXCL11, CXCL6, PPBP |
| Tissue | bone.marrow, whole.blood |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1DN3 (NMR - ) 1F9Q (X-ray 2.00A ) 1F9R (X-ray 2.00A ) 1F9S (X-ray 2.38A ) 1PFM (NMR - ) 1PFN (NMR - ) 1RHP (X-ray 2.40A ) 4R9W (X-ray 2.50A ) 4R9Y (X-ray 4.11A ) 4RAU (X-ray 3.74A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:7644496}. |
| Mouse PG classification | NA |
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