| Gene Information | |
|---|---|
| Gene Name | CD1E |
| Organism | Homo sapiens (Human) |
| Gene Length | 388 |
| Protein Names | T-cell surface glycoprotein CD1e, membrane-associated (hCD1e) (R2G1) (CD antigen CD1e) [Cleaved into: T-cell surface glycoprotein CD1e, soluble (sCD1e)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000158488 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P15812 |
| Gene Card | CD1E |
| Uniprot ID | P15812 |
| Pfam | PF07654; PF16497 |
| In ASD | no |
| Allosteric Prediction | no (-0.320695131) |
| Ortholog in Animals | Alpaca_ CD1E ( ortholog_one2one ) GuineaPig_ CD1E ( ortholog_one2one ) Macaque_ CD1E ( ortholog_one2one ) Pig_ CD1E ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HLA-B, HLA-E, HLA-A, HLA-F, HLA-G, HLA-C, MR1, AZGP1, MICA, HFE, MICB, CD1D, CD1A, CD1C, CD1B, ULBP2, RAET1L, FCGRT, RAET1G, RAET1E, ULBP3, ULBP1 |
| Tissue | NA |
| Tissue Specificity | Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues. {ECO:0000269|PubMed:10948205}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 3S6C (X-ray 2.90A ) |
| DBSNP | rs3180089 rs2873587 rs1065457 rs35116276 rs199655202 rs200741122 |
| Subcellular location [CC] | [T-cell surface glycoprotein CD1e, membrane-associated]: Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome. Late endosome. Note=Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells.; [T-cell surface glycoprotein CD1e, soluble]: Lysosome lumen. |
| Mouse PG classification | NA |
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