| Gene Information | |
|---|---|
| Gene Name | PEX6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 980 |
| Protein Names | Peroxisomal ATPase PEX6 (EC 3.6.4.-) (Peroxin-6) (Peroxisomal biogenesis factor 6) (Peroxisomal-type ATPase 1) (Peroxisome assembly factor 2) (PAF-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000124587 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q13608 |
| Gene Card | PEX6 |
| Uniprot ID | Q13608 |
| Pfam | PF00004 |
| In ASD | no |
| Allosteric Prediction | no (-0.94692926) |
| Ortholog in Animals | Alpaca_ PEX6 ( ortholog_one2one ) Dog_ PEX6 ( ortholog_one2one ) GuineaPig_ PEX6 ( ortholog_one2one ) Macaque_ PEX6 ( ortholog_one2one ) Mouse_ Pex6 ( ortholog_one2one ) Pig_ PEX6 ( ortholog_one2one ) Rat_ Pex6 ( ortholog_one2one ) Rabbit_ PEX6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | VCP, NVL, SPATA5L1, PEX1, SPATA5 |
| Tissue | NA |
| Tissue Specificity | Expressed in the retina, at higher levels in the photoreceptor layer at the joint between the outer and inner segments. {ECO:0000269|PubMed:26593283}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002990(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs61752141 rs886037780 rs886037781 rs886037779 rs61753219 rs1554127531 rs387906809 rs61753224 rs34324426 rs769896492 rs35830695 rs61753229 rs61753228 rs267608244 rs61753231 rs61753230 rs2274516 rs886037782 rs34551839 rs1129187 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:16854980}. Peroxisome membrane {ECO:0000269|PubMed:11355018, ECO:0000269|PubMed:12717447, ECO:0000269|PubMed:16854980, ECO:0000269|PubMed:21362118}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:26593283}. Note=Associated with peroxisomal membranes; anchored by PEX26 to peroxisome membranes (PubMed:12717447, PubMed:16854980). Localized at the base of the outer segment of photoreceptor cells (PubMed:26593283). {ECO:0000269|PubMed:12717447, ECO:0000269|PubMed:16854980, ECO:0000269|PubMed:26593283}. |
| Mouse PG classification | NA |
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