| Gene Information | |
|---|---|
| Gene Name | ITGAX |
| Organism | Homo sapiens (Human) |
| Gene Length | 1163 |
| Protein Names | Integrin alpha-X (CD11 antigen-like family member C) (Leu M5) (Leukocyte adhesion glycoprotein p150,95 alpha chain) (Leukocyte adhesion receptor p150,95) (CD antigen CD11c) |
| Target Name | integrin alpha-x |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000140678 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P20702 |
| Gene Card | ITGAX |
| Uniprot ID | P20702 |
| Pfam | PF01839; PF00357; PF08441; PF00092 |
| In ASD | yes |
| Allosteric Prediction | yes (0.50721746) |
| Ortholog in Animals | Alpaca_ ITGAX ( ortholog_one2one ) Macaque_ ITGAX ( ortholog_one2one ) Mouse_ Itgax ( ortholog_one2one ) Rat_ Itgax ( ortholog_one2one ) Rabbit_ ITGAX ( ortholog_one2one ) |
| Ohnologs | ITGA11, ITGA10 |
| Paralogs | ITGA10, ITGA4, ITGAE, ITGA2, ITGAD, ITGA5, ITGA6, ITGAV, ITGA7, ITGA8, ITGAL, ITGA3, ITGA2B, ITGA11, ITGA1, ITGAM, ITGA9 |
| Tissue | spleen, whole.blood |
| Tissue Specificity | Predominantly expressed in monocytes and granulocytes. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1N3Y (X-ray 1.65A ) 2LUV (NMR - ) 3K6S (X-ray 3.50A ) 3K71 (X-ray 3.95A ) 3K72 (X-ray 3.70A ) 4NEH (X-ray 2.75A ) 4NEN (X-ray 2.90A ) 5ES4 (X-ray 3.30A ) |
| DBSNP | rs2230424 rs1574566 rs2230428 rs2230429 rs17853815 rs189592567 rs2230427 rs181404376 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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