Gene Information
Gene NamePEX5
OrganismHomo sapiens (Human)
Gene Length639
Protein NamesPeroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1)
Target NameNA
Target TypeNA
Gene Age1714 ( ENSG00000139197 )
3 ( ENSG00000288217 )
Evolutionary StageEuk+Bac
AlphaFoldDBP50542
Gene CardPEX5
Uniprot IDP50542
PfamPF13181
In ASDno
Allosteric Predictionno (-0.488888418)
Ortholog in AnimalsAlpaca_ PEX5 ( ortholog_one2one )
Dog_ PEX5 ( ortholog_one2one )
GuineaPig_ PEX5 ( ortholog_one2one )
Macaque_ PEX5 ( ortholog_one2one )
Mouse_ Pex5 ( ortholog_one2one )
Pig_ PEX5 ( ortholog_one2one )
Rat_ Pex5 ( ortholog_one2one )
Rabbit_ PEX5 ( ortholog_one2one )
OhnologsPEX5L
ParalogsPEX5L
TissueNA
Tissue SpecificityDetected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:7706321, ECO:0000269|PubMed:7719337, ECO:0000269|PubMed:7790377}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1FCH  (X-ray  2.20A  )  2C0L  (X-ray  2.30A  )  2C0M  (X-ray  2.50A  )  2J9Q  (X-ray  2.65A  )  2W84  (NMR  -  )  3R9A  (X-ray  2.35A  )  4BXU  (NMR  -  )  4KXK  (X-ray  2.90A  )  4KYO  (X-ray  2.20A  ) 
DBSNP rs61752138 
Subcellular location [CC]Cytoplasm, cytosol {ECO:0000269|PubMed:11336669, ECO:0000269|PubMed:16314507, ECO:0000269|PubMed:7719337}. Peroxisome matrix {ECO:0000269|PubMed:11336669, ECO:0000269|PubMed:11546814, ECO:0000269|PubMed:16314507, ECO:0000269|PubMed:24662292, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:33389129, ECO:0000269|PubMed:7706321, ECO:0000269|PubMed:7719337}. Note=Cycles between the cytosol and the peroxisome matrix (PubMed:11336669, PubMed:16314507). Following binding to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, recruited to the docking complex, composed of PEX13 and PEX14, leading to translocation into the peroxisome matrix along with cargo proteins (By similarity). Export and recycling to the cytosol is initiated by binding to the PEX2-PEX10-PEX12 ligase complex via its unstructured N-terminus that inserts into the ligase pore and emerges in the cytosol (By similarity). Cys-11 of PEX5 is then monoubiquitinated, promoting its extraction from peroxisomal membrane by the PEX1-PEX6 AAA ATPase complex (PubMed:16314507, PubMed:19208625, PubMed:24118911, PubMed:29884772). Extraction is accompanied by unfolding of the TPR repeats and release of bound cargo in the peroxisome matrix (By similarity). The TPR repeats refold in the cytosol and ubiquitination is removed by deubiquitinating enzymes, resetting PEX5 for a subsequent import cycle (By similarity). {ECO:0000250|UniProtKB:A0A1L8FDW4, ECO:0000269|PubMed:11336669, ECO:0000269|PubMed:16314507, ECO:0000269|PubMed:19208625, ECO:0000269|PubMed:24118911, ECO:0000269|PubMed:29884772}.
Mouse PG classificationNA
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