| Gene Information | |
|---|---|
| Gene Name | PER2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1255 |
| Protein Names | Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000132326 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O15055 |
| Gene Card | PER2 |
| Uniprot ID | O15055 |
| Pfam | PF08447; PF12114 |
| In ASD | no |
| Allosteric Prediction | yes (0.545052977) |
| Ortholog in Animals | Alpaca_ PER2 ( ortholog_one2one ) Dog_ PER2 ( ortholog_one2one ) GuineaPig_ PER2 ( ortholog_one2one ) Macaque_ PER2 ( ortholog_one2one ) Mouse_ Per2 ( ortholog_one2one ) Pig_ PER2 ( ortholog_one2one ) Rat_ Per2 ( ortholog_one2one ) Rabbit_ PER2 ( ortholog_one2one ) |
| Ohnologs | PER1, PER3 |
| Paralogs | PER3, PER1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Found in heart, brain, placenta, lung, liver, skeleatal muscle, kidney and pancreas. High levels in skeletal muscle and pancreas. Low levels in lung. Isoform 2 is expressed in keratinocytes (at protein level). {ECO:0000269|PubMed:9427249}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.034018(Rat);0.058069(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6OF7 (X-ray 3.11A ) |
| DBSNP | rs35572922 rs121908635 rs4429421 rs35333999 rs35998480 rs934945 |
| Subcellular location [CC] | [Isoform 1]: Nucleus {ECO:0000269|PubMed:22274616}. Cytoplasm {ECO:0000250|UniProtKB:O54943}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O54943}. Note=Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Translocate to the nucleus after phosphorylation by CSNK1D or CSNK1E. Also translocated to the nucleus by CRY1 or CRY2. PML regulates its nuclear localization. {ECO:0000250|UniProtKB:O54943}.; [Isoform 2]: Nucleus, nucleolus {ECO:0000269|PubMed:24202686}. |
| Mouse PG classification | LPG |
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