| Gene Information | |
|---|---|
| Gene Name | PER1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1290 |
| Protein Names | Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000179094 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O15534 |
| Gene Card | PER1 |
| Uniprot ID | O15534 |
| Pfam | PF08447; PF12114 |
| In ASD | no |
| Allosteric Prediction | no (-0.04375438) |
| Ortholog in Animals | Alpaca_ PER1 ( ortholog_one2one ) Dog_ PER1 ( ortholog_one2one ) GuineaPig_ PER1 ( ortholog_one2one ) Macaque_ PER1 ( ortholog_one2one ) Mouse_ Per1 ( ortholog_one2one ) Pig_ PER1 ( ortholog_one2one ) Rat_ Per1 ( ortholog_one2one ) Rabbit_ PER1 ( ortholog_one2one ) |
| Ohnologs | PER3, PER2 |
| Paralogs | PER3, PER2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed in hair follicles (at protein level).Found in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, kidney, spleen, thymus, prostate, testis, ovary and small intestine. Highest level in skeletal muscle. {ECO:0000269|PubMed:14750904, ECO:0000269|PubMed:24005054, ECO:0000269|PubMed:9333243, ECO:0000269|PubMed:9427249}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.034636(Rat);0.060701(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1464745710 rs2585405 rs3027193 rs1323588262 rs761958964 |
| Subcellular location [CC] | Nucleus. Cytoplasm. Note=Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation. Translocate to the nucleus after phosphorylation by CSNK1D or CSNK1E. Also translocated to the nucleus by CRY1 or CRY2 (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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