Gene Information
Gene NamePEMT
OrganismHomo sapiens (Human)
Gene Length199
Protein NamesPhosphatidylethanolamine N-methyltransferase (PEAMT) (PEMT) (EC 2.1.1.17) (EC 2.1.1.71) (PEMT2) (Phospholipid methyltransferase) (PLMT)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000133027 )
Evolutionary StageEukaryota
AlphaFoldDBQ9UBM1
Gene CardPEMT
Uniprot IDQ9UBM1
PfamPF04191
In ASDno
Allosteric Predictionyes (0.265875127)
Ortholog in AnimalsAlpaca_ PEMT ( ortholog_one2one )
Dog_ PEMT ( ortholog_one2one )
GuineaPig_ PEMT ( ortholog_one2one )
Macaque_ PEMT ( ortholog_one2one )
Mouse_ Pemt ( ortholog_one2one )
Rat_ Pemt ( ortholog_one2one )
Rabbit_ PEMT ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityPrimarily expressed in liver (at protein level). {ECO:0000269|PubMed:12431977}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs70959686  rs897453  rs897453  rs7946  rs70965427  rs7215880 
Subcellular location [CC]Endoplasmic reticulum {ECO:0000269|PubMed:15927961}. Note=localized in the endoplasmic reticulum (ER) of the liver and in a lipid metabolism-rich region of the ER known as mitochondria-associated membranes (PubMed:15927961). Adopts a topography within the ER membrane that positions both termini in the cytosol (PubMed:12431977). {ECO:0000269|PubMed:12431977, ECO:0000303|PubMed:15927961}.;
[Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20860552};
Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03216}. Mitochondrion membrane {ECO:0000255|HAMAP-Rule:MF_03216};
Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03216}. Note=Found in endoplasmic reticulum where most PEMT activity is generated and in mitochondria. {ECO:0000269|PubMed:12431977}.;
[Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20860552};
Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03216}.
Mouse PG classificationNA
click here to return to the previous page