| Gene Information | |
|---|---|
| Gene Name | PDXP |
| Organism | Homo sapiens (Human) |
| Gene Length | 296 |
| Protein Names | Chronophin (EC 3.1.3.16) (EC 3.1.3.74) (Pyridoxal phosphate phosphatase) (PLP phosphatase) |
| Target Name | pyridoxal phosphate phosphatase |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000241360 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q96GD0 |
| Gene Card | PDXP |
| Uniprot ID | Q96GD0 |
| Pfam | PF13344 |
| In ASD | no |
| Allosteric Prediction | yes (0.504951677) |
| Ortholog in Animals | Alpaca_ PDXP ( ortholog_one2one ) Dog_ PDXP ( ortholog_one2one ) GuineaPig_ PDXP ( ortholog_one2one ) Mouse_ Pdxp ( ortholog_one2one ) Pig_ PDXP ( ortholog_one2one ) Rat_ Pdxp ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PGP, LHPP, HDHD2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed (at protein level) (PubMed:23223568). Highly expressed in all the regions of central nerve system except the spinal cord. Also expressed at high level in liver and testis. In fetus, it is weakly expressed in all organs except brain (PubMed:14522954, PubMed:15580268). {ECO:0000269|PubMed:14522954, ECO:0000269|PubMed:15580268, ECO:0000269|PubMed:23223568}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2CFR (X-ray 2.40A ) 2CFS (X-ray 2.40A ) 2CFT (X-ray 1.80A ) 2OYC (X-ray 1.72A ) 2P27 (X-ray 1.90A ) 2P69 (X-ray 2.25A ) 5GYN (X-ray 2.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:15580268}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15580268}. Cell projection, ruffle membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Diffusely distributed throughout the cytosol during pro-metaphase and metaphase. Detected at the dynamic cell poles during telophase. Detected at the cleavage furrow and contractile ring during cytokinesis. Transiently detected at the plasma membrane in late stages of cytokinesis. Detected at the midbody. {ECO:0000269|PubMed:15580268}. |
| Mouse PG classification | NA |
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