| Gene Information | |
|---|---|
| Gene Name | DHRS4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 278 |
| Protein Names | Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase) (CR) (NADPH-dependent retinol dehydrogenase/reductase) (NRDR) (humNRDR) (Peroxisomal short-chain alcohol dehydrogenase) (PSCD) (SCAD-SRL) (Short chain dehydrogenase/reductase family 25C member 2) (Protein SDR25C2) (Short-chain dehydrogenase/reductase family member 4) |
| Target Name | dehydrogenase/reductase sdr family member 4 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000157326 ) 3 ( ENSG00000284807 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9BTZ2 |
| Gene Card | DHRS4 |
| Uniprot ID | Q9BTZ2 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.087643474) |
| Ortholog in Animals | Alpaca_ DHRS4 ( ortholog_one2one ) Dog_ DHRS4 ( ortholog_one2many ) Macaque_ DHRS4 ( ortholog_one2one ) Mouse_ Dhrs4 ( ortholog_one2many ) Pig_ DHRS4 ( ortholog_one2many ) Rat_ Dhrs4 ( ortholog_one2many ) Rabbit_ DHRS4 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | DHRS7C, DHRS7, HSD11B1, RDH8, CBR3, HSDL2, DHRS7B, DHRS2, HSD11B1L, DHRS11, CBR1, DHRS1, DHRS4L2 |
| Tissue | NA |
| Tissue Specificity | [Isoform 1]: Predominantly expressed in normal cervix (at protein level). {ECO:0000269|PubMed:17230527}.; [Isoform 4]: Expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). {ECO:0000269|PubMed:17230527}.; [Isoform 5]: Expressed in a few neoplastic cervical tissues. {ECO:0000269|PubMed:17230527}.; [Isoform 6]: Expressed in a few neoplastic cervical tissues. {ECO:0000269|PubMed:17230527}.; [Isoform 8]: High expression in liver. {ECO:0000269|PubMed:23128527}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3O4R (X-ray 1.70A ) |
| DBSNP | rs1043442 rs1043650 |
| Subcellular location [CC] | [Isoform 1]: Peroxisome {ECO:0000269|PubMed:10333503, ECO:0000269|PubMed:17230527}. Note=Isoform 4 is not peroxisomal. {ECO:0000269|PubMed:17230527}.; [Isoform 7]: Nucleus {ECO:0000269|PubMed:22227495}. |
| Mouse PG classification | NA |
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