| Gene Information | |
|---|---|
| Gene Name | PLEKHA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 404 |
| Protein Names | Pleckstrin homology domain-containing family A member 1 (PH domain-containing family A member 1) (Tandem PH domain-containing protein 1) (TAPP-1) |
| Target Name | pleckstrin homology domain-containing family a member 1 |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000107679 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9HB21 |
| Gene Card | PLEKHA1 |
| Uniprot ID | Q9HB21 |
| Pfam | PF00169 |
| In ASD | no |
| Allosteric Prediction | no (-0.295360633) |
| Ortholog in Animals | Alpaca_ PLEKHA1 ( ortholog_one2one ) Dog_ PLEKHA1 ( ortholog_one2one ) GuineaPig_ PLEKHA1 ( ortholog_one2one ) Macaque_ PLEKHA1 ( ortholog_one2one ) Mouse_ Plekha1 ( ortholog_one2one ) Pig_ PLEKHA1 ( ortholog_one2one ) Rat_ Plekha1 ( ortholog_one2one ) Rabbit_ PLEKHA1 ( ortholog_one2one ) |
| Ohnologs | PLEKHA2 |
| Paralogs | PLEKHA2 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in skeletal muscle, thymus, pancreas, placenta and lung. Detected at low levels in brain, heart, peripheral blood leukocytes, testis, ovary, spinal cord, thyroid, kidney, liver, small intestine and colon. {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:12101241}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1EAZ (X-ray 1.40A ) |
| DBSNP | rs1045216 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11802782, ECO:0000269|PubMed:12101241}. Cell membrane {ECO:0000269|PubMed:11802782, ECO:0000269|PubMed:12101241}; Peripheral membrane protein. Nucleus {ECO:0000269|PubMed:11802782, ECO:0000269|PubMed:12101241}. Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2. {ECO:0000269|PubMed:11802782}. |
| Mouse PG classification | NA |
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