| Gene Information | |
|---|---|
| Gene Name | PDS |
| Organism | Homo sapiens (Human) |
| Gene Length | 190 |
| Protein Names | Prostaglandin-H2 D-isomerase (EC 5.3.99.2) (Beta-trace protein) (Cerebrin-28) (Glutathione-independent PGD synthase) (Lipocalin-type prostaglandin-D synthase) (L-PGDS) (Prostaglandin-D2 synthase) (PGD2 synthase) (PGDS) (PGDS2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P41222 |
| Gene Card | PTGDS |
| Uniprot ID | P41222 |
| Pfam | PF00061 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Abundant in the brain and CNS, where it is expressed in tissues of the blood-brain barrier and secreted into the cerebro-spinal fluid. Abundantly expressed in the heart. In the male reproductive system, it is expressed in the testis, epididymis and prostate, and is secreted into the seminal fluid. Expressed in the eye and secreted into the aqueous humor. Lower levels detected in various tissue fluids such as serum, normal urine, ascitic fluid and tear fluid. Also found in a number of other organs including ovary, fimbriae of the fallopian tubes, kidney, leukocytes. {ECO:0000269|PubMed:10462696, ECO:0000269|PubMed:11882588, ECO:0000269|PubMed:7692978, ECO:0000269|PubMed:8599604, ECO:0000269|PubMed:8761996, ECO:0000269|PubMed:9065498, ECO:0000269|PubMed:9405674, ECO:0000269|PubMed:9475419, ECO:0000269|PubMed:9844724}. |
| Pharmacological Animal Models | 0.032198(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2WWP (X-ray 2.00A ) 3O19 (X-ray 1.66A ) 3O22 (X-ray 1.40A ) 3O2Y (X-ray 1.70A ) 4IMN (X-ray 2.09A ) 4IMO (X-ray 1.88A ) 4ORR (X-ray 1.40A ) 4ORS (X-ray 1.40A ) 4ORU (X-ray 1.55A ) 4ORW (X-ray 1.66A ) 4ORX (X-ray 1.60A ) 4ORY (X-ray 1.80A ) 4OS0 (X-ray 1.75A ) 4OS3 (X-ray 1.40A ) 4OS8 (X-ray 1.69A ) 5WY9 (X-ray 1.45A ) |
| DBSNP | rs11552179 |
| Subcellular location [CC] | Rough endoplasmic reticulum {ECO:0000269|PubMed:9065498}. Nucleus membrane {ECO:0000269|PubMed:9065498}. Golgi apparatus {ECO:0000269|PubMed:9065498}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:9065498}. Secreted {ECO:0000269|PubMed:9065498}. Note=Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted. |
| Mouse PG classification | NA |
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