| Gene Information | |
|---|---|
| Gene Name | ASAP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1006 |
| Protein Names | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (Development and differentiation-enhancing factor 2) (Paxillin-associated protein with ARF GAP activity 3) (PAG3) (Pyk2 C-terminus-associated protein) (PAP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000151693 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O43150 |
| Gene Card | ASAP2 |
| Uniprot ID | O43150 |
| Pfam | PF12796; PF01412; PF00169; PF14604 |
| In ASD | no |
| Allosteric Prediction | no (-0.294983033) |
| Ortholog in Animals | Alpaca_ ASAP2 ( ortholog_one2one ) Dog_ ASAP2 ( ortholog_one2one ) GuineaPig_ ASAP2 ( ortholog_one2one ) Macaque_ ASAP2 ( ortholog_one2one ) Mouse_ Asap2 ( ortholog_one2one ) Pig_ ASAP2 ( ortholog_one2one ) Rat_ Asap2 ( ortholog_one2one ) Rabbit_ ASAP2 ( ortholog_one2one ) |
| Ohnologs | ASAP1, ASAP3 |
| Paralogs | ASAP1, ACAP3, ARAP2, GIT1, ARAP3, AGFG1, ADAP1, SMAP1, AGAP1, ACAP2, AGAP3, AGAP4, AGAP6, AGAP9, AGAP5, ARFGAP1, ASAP3, APPL1, ARFGAP2, ARAP1, AGFG2, APPL2, ARFGAP3, GIT2, ADAP2, SMAP2, AGAP2, ACAP1 |
| Tissue | NA |
| Tissue Specificity | Detected in heart, brain, placenta, kidney, monocytes and pancreas. {ECO:0000269|PubMed:10022920}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2715860 |
| Subcellular location [CC] | Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Note=Colocalizes with F-actin and ARF6 in phagocytic cups. |
| Mouse PG classification | NA |
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