| Gene Information | |
|---|---|
| Gene Name | S1PR3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 378 |
| Protein Names | Sphingosine 1-phosphate receptor 3 (S1P receptor 3) (S1P3) (Endothelial differentiation G-protein coupled receptor 3) (Sphingosine 1-phosphate receptor Edg-3) (S1P receptor Edg-3) |
| Target Name | sphingosine 1-phosphate receptor 3 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000213694 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q99500 |
| Gene Card | S1PR3 |
| Uniprot ID | Q99500 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999987088) |
| Ortholog in Animals | Alpaca_ S1PR3 ( ortholog_one2one ) Dog_ S1PR3 ( ortholog_one2one ) GuineaPig_ S1PR3 ( ortholog_one2one ) Macaque_ S1PR3 ( ortholog_one2one ) Mouse_ S1pr3 ( ortholog_one2one ) Pig_ S1PR3 ( ortholog_one2one ) Rat_ S1pr3 ( ortholog_one2one ) Rabbit_ S1PR3 ( ortholog_one2one ) |
| Ohnologs | LPAR2, S1PR4, S1PR5, S1PR1, LPAR3, LPAR1 |
| Paralogs | GPR3, GPR119, GPR6, GPR12, CNR1, CNR2, MC5R, MC1R, MC2R, MC3R, MC4R, LPAR1, LPAR2, LPAR3, S1PR1, S1PR5, S1PR2, S1PR4 |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7C4S (X-ray 3.20A ) 7EW2 (EM 3.10A ) 7EW3 (EM 3.10A ) 7EW4 (EM 3.20A ) |
| DBSNP | rs34075341 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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