| Gene Information | |
|---|---|
| Gene Name | PDLIM3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 364 |
| Protein Names | PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha-actinin-2-associated LIM protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000154553 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q53GG5 |
| Gene Card | PDLIM3 |
| Uniprot ID | Q53GG5 |
| Pfam | PF15936; PF00412; PF00595 |
| In ASD | no |
| Allosteric Prediction | no (-0.759919529) |
| Ortholog in Animals | Alpaca_ PDLIM3 ( ortholog_one2one ) Dog_ PDLIM3 ( ortholog_one2one ) GuineaPig_ PDLIM3 ( ortholog_one2one ) Macaque_ PDLIM3 ( ortholog_one2one ) Mouse_ Pdlim3 ( ortholog_one2one ) Pig_ PDLIM3 ( ortholog_one2one ) Rat_ Pdlim3 ( ortholog_one2one ) Rabbit_ PDLIM3 ( ortholog_one2one ) |
| Ohnologs | PDLIM1, PDLIM4 |
| Paralogs | PDLIM2, PDLIM1, LDB3, PDLIM5, PDLIM7, PDLIM4, PRICKLE4 |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is highly expressed in differentiated skeletal muscle. Isoform 2 is heart-specific. {ECO:0000269|PubMed:9334352}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11944325 |
| Subcellular location [CC] | Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:10063829}. Note=Localizes to myofiber Z-lines. |
| Mouse PG classification | NA |
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