Gene Information
Gene NamePREPL
OrganismHomo sapiens (Human)
Gene Length727
Protein NamesProlyl endopeptidase-like (EC 3.4.21.-) (Prolylendopeptidase-like)
Target Nameprolyl endopeptidase-like
Target TypeLiterature-reported target
Gene Age645 ( ENSG00000138078 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ4J6C6
Gene CardPREPL
Uniprot IDQ4J6C6
PfamPF00326; PF02897
In ASDno
Allosteric Predictionno (-0.672706415)
Ortholog in AnimalsAlpaca_ PREPL ( ortholog_one2one )
Dog_ PREPL ( ortholog_one2one )
GuineaPig_ PREPL ( ortholog_one2one )
Macaque_ PREPL ( ortholog_one2one )
Mouse_ Prepl ( ortholog_one2one )
Pig_ PREPL ( ortholog_one2one )
Rat_ Prepl ( ortholog_one2one )
Rabbit_ PREPL ( ortholog_one2one )
OhnologsNA
ParalogsPREP
TissueNA
Tissue SpecificityExpressed in pyramidal neurons of the temporal cortex and neocortex (at protein level) (PubMed:23485813). Widely expressed (PubMed:15913950, PubMed:16385448). Expressed at higher level in brain, skeletal muscle, heart and kidney (PubMed:15913950, PubMed:16385448). Expressed at the endplates in the neuromuscular junction (PubMed:24610330). {ECO:0000269|PubMed:15913950, ECO:0000269|PubMed:16385448, ECO:0000269|PubMed:23485813, ECO:0000269|PubMed:24610330}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 7OBM  (X-ray  3.10A  ) 
DBSNP NA 
Subcellular location [CC]Cytoplasm, cytosol {ECO:0000269|PubMed:16385448, ECO:0000269|PubMed:23485813}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q8C167}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8C167}. Golgi apparatus {ECO:0000250|UniProtKB:Q8C167}. Nucleus {ECO:0000269|PubMed:23485813}. Note=Co-localizes with AP-1 in the trans-Golgi network (By similarity). Co-localizes with MAP2 and ACTB on the cytoskeleton (By similarity). Co-localizes with STX6 and GOSR2 at the Golgi apparatus (By similarity). {ECO:0000250|UniProtKB:Q8C167}.
Mouse PG classificationNA
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