| Gene Information | |
|---|---|
| Gene Name | CRYZ |
| Organism | Homo sapiens (Human) |
| Gene Length | 329 |
| Protein Names | Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta-crystallin) |
| Target Name | quinone oxidoreductase |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000116791 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q08257 |
| Gene Card | CRYZ |
| Uniprot ID | Q08257 |
| Pfam | PF08240; PF00107 |
| In ASD | no |
| Allosteric Prediction | yes (0.197478115) |
| Ortholog in Animals | Alpaca_ CRYZ ( ortholog_one2one ) Dog_ CRYZ ( ortholog_one2many ) GuineaPig_ CRYZ ( ortholog_one2one ) Mouse_ Cryz ( ortholog_one2one ) Pig_ CRYZ ( ortholog_one2one ) Rat_ Cryz ( ortholog_one2one ) Rabbit_ CRYZ ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MECR, RTN4IP1, PTGR2, TP53I3, CRYZL1, PTGR3, ADH6, ADH4, SORD, ADH1B, ADH1A, ADH1C, VAT1L, PTGR1, ADH5, ADH7, VAT1 |
| Tissue | NA |
| Tissue Specificity | Only very low amounts in the lens. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1YB5 (X-ray 1.85A ) |
| DBSNP | rs11551729 rs3819946 rs17095822 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:20103721}. |
| Mouse PG classification | NA |
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