| Gene Information | |
|---|---|
| Gene Name | PDK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 556 |
| Protein Names | 3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1) |
| Target Name | [pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000152256 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O15530 |
| Gene Card | PDPK1 |
| Uniprot ID | O15530 |
| Pfam | PF14593; PF00069 |
| In ASD | yes |
| Allosteric Prediction | yes (0.735695427) |
| Ortholog in Animals | Alpaca_ PDK1 ( ortholog_one2one ) Dog_ PDK1 ( ortholog_one2one ) GuineaPig_ PDK1 ( ortholog_one2one ) Macaque_ PDK1 ( ortholog_one2one ) Mouse_ Pdk1 ( ortholog_one2one ) Pig_ PDK1 ( ortholog_one2one ) Rat_ Pdk1 ( ortholog_one2one ) |
| Ohnologs | PDK4, PDK2 |
| Paralogs | PDK4, PDK2, PDK3, BCKDK |
| Tissue | NA |
| Tissue Specificity | Appears to be expressed ubiquitously. The Tyr-9 phosphorylated form is markedly increased in diseased tissue compared with normal tissue from lung, liver, colon and breast. {ECO:0000269|PubMed:18024423}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1H1W (X-ray 2.00A ) 1OKY (X-ray 2.30A ) 1OKZ (X-ray 2.51A ) 1UU3 (X-ray 1.70A ) 1UU7 (X-ray 1.90A ) 1UU8 (X-ray 2.50A ) 1UU9 (X-ray 1.95A ) 1UVR (X-ray 2.81A ) 1W1D (X-ray 1.50A ) 1W1G (X-ray 1.45A ) 1W1H (X-ray 1.45A ) 1Z5M (X-ray 2.17A ) 2BIY (X-ray 1.95A ) 2PE0 (X-ray 2.35A ) 2PE1 (X-ray 2.14A ) 2PE2 (X-ray 2.13A ) 2R7B (X-ray 2.70A ) 2VKI (X-ray 1.80A ) 2XCH (X-ray 2.00A ) 2XCK (X-ray 2.30A ) 3H9O (X-ray 2.30A ) 3HRC (X-ray 1.91A ) 3HRF (X-ray 1.90A ) 3ION (X-ray 2.40A ) 3IOP (X-ray 2.20A ) 3NAX (X-ray 1.75A ) 3NAY (X-ray 2.60A ) 3NUN (X-ray 2.20A ) 3NUS (X-ray 2.75A ) 3NUU (X-ray 1.98A ) 3NUY (X-ray 2.10A ) 3ORX (X-ray 2.20A ) 3ORZ (X-ray 2.00A ) 3OTU (X-ray 2.10A ) 3PWY (X-ray 3.50A ) 3QC4 (X-ray 1.80A ) 3QCQ (X-ray 2.50A ) 3QCS (X-ray 2.49A ) 3QCX (X-ray 2.30A ) 3QCY (X-ray 2.20A ) 3QD0 (X-ray 1.99A ) 3QD3 (X-ray 2.00A ) 3QD4 (X-ray 2.30A ) 3RCJ (X-ray 1.70A ) 3RWP (X-ray 1.92A ) 3RWQ (X-ray 2.55A ) 3SC1 (X-ray 2.70A ) 4A06 (X-ray 2.00A ) 4A07 (X-ray 1.85A ) 4AW0 (X-ray 1.43A ) 4AW1 (X-ray 1.68A ) 4CT1 (X-ray 1.85A ) 4CT2 (X-ray 1.25A ) 4RQK (X-ray 1.55A ) 4RQV (X-ray 1.50A ) 4RRV (X-ray 1.41A ) 4XX9 (X-ray 1.40A ) 5ACK (X-ray 1.24A ) 5HKM (X-ray 2.10A ) 5HNG (X-ray 3.01A ) 5HO7 (X-ray 3.00A ) 5HO8 (X-ray 2.70A ) 5LVL (X-ray 1.40A ) 5LVM (X-ray 1.26A ) 5LVN (X-ray 1.38A ) 5LVO (X-ray 1.09A ) 5LVP (X-ray 2.50A ) 5MRD (X-ray 1.41A ) 6WJQ (X-ray 2.71A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Cell junction, focal adhesion. Note=Tyrosine phosphorylation seems to occur only at the cell membrane. Translocates to the cell membrane following insulin stimulation by a mechanism that involves binding to GRB14 and INSR. SRC and HSP90 promote its localization to the cell membrane. Its nuclear localization is dependent on its association with PTPN6 and its phosphorylation at Ser-396. Restricted to the nucleus in neuronal cells while in non-neuronal cells it is found in the cytoplasm. The Ser-241 phosphorylated form is distributed along the perinuclear region in neuronal cells while in non-neuronal cells it is found in both the nucleus and the cytoplasm. IGF1 transiently increases phosphorylation at Ser-241 of neuronal PDPK1, resulting in its translocation to other cellular compartments. The tyrosine-phosphorylated form colocalizes with PTK2B in focal adhesions after angiotensin II stimulation. |
| Mouse PG classification | NA |
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