Gene Information
Gene NameFTO
OrganismHomo sapiens (Human)
Gene Length505
Protein NamesAlpha-ketoglutarate-dependent dioxygenase FTO (Fat mass and obesity-associated protein) (U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (EC 1.14.11.-) (U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO) (EC 1.14.11.-) (mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (m6A(m)-demethylase FTO) (EC 1.14.11.-) (mRNA N(6)-methyladenosine demethylase FTO) (EC 1.14.11.53) (tRNA N1-methyl adenine demethylase FTO) (EC 1.14.11.-)
Target Namealpha-ketoglutarate-dependent dioxygenase fto
Target TypeNA
Gene Age645 ( ENSG00000140718 )
Evolutionary StageEukaryota
AlphaFoldDBQ9C0B1
Gene CardFTO
Uniprot IDQ9C0B1
PfamPF12934; PF12933
In ASDno
Allosteric Predictionno (-0.165329163)
Ortholog in AnimalsAlpaca_ FTO ( ortholog_one2one )
Dog_ FTO ( ortholog_one2one )
GuineaPig_ FTO ( ortholog_one2one )
Macaque_ FTO ( ortholog_one2one )
Mouse_ Fto ( ortholog_one2one )
Pig_ FTO ( ortholog_one2one )
Rat_ Fto ( ortholog_one2one )
Rabbit_ FTO ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityUbiquitously expressed, with relatively high expression in adrenal glands and brain;
especially in hypothalamus and pituitary (PubMed:17434869, PubMed:17496892). Highly expressed in highly expressed in acute myeloid leukemias (AML) with t(11;11)(q23;23) with KMT2A/MLL1 rearrangements, t(15;17)(q21;q21)/PML-RARA, FLT3-ITD, and/or NPM1 mutations (PubMed:28017614). {ECO:0000269|PubMed:17434869, ECO:0000269|PubMed:17496892, ECO:0000269|PubMed:28017614}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3LFM  (X-ray  2.50A  )  4CXW  (X-ray  3.10A  )  4CXX  (X-ray  2.76A  )  4CXY  (X-ray  2.65A  )  4IDZ  (X-ray  2.46A  )  4IE0  (X-ray  2.53A  )  4IE4  (X-ray  2.50A  )  4IE5  (X-ray  1.95A  )  4IE6  (X-ray  2.50A  )  4IE7  (X-ray  2.60A  )  4QHO  (X-ray  2.37A  )  4QKN  (X-ray  2.20A  )  4ZS2  (X-ray  2.16A  )  4ZS3  (X-ray  2.45A  )  5DAB  (X-ray  2.10A  )  5F8P  (X-ray  2.20A  )  5ZMD  (X-ray  3.30A  )  6AEJ  (X-ray  2.80A  )  6AK4  (X-ray  2.80A  )  6AKW  (X-ray  2.20A  )  7CKK  (X-ray  2.35A  )  7E8Z  (X-ray  2.55A  )  7WCV  (X-ray  2.30A  ) 
DBSNP rs121918214  rs781028867  rs745616565  rs16952624 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:22002720, ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:28002401, ECO:0000269|PubMed:30197295}. Nucleus speckle {ECO:0000269|PubMed:22002720}. Cytoplasm {ECO:0000269|PubMed:30197295}. Note=Localizes mainly in the nucleus, where it is able to demethylate N(6)-methyladenosine (m6A) and N(6),2'-O-dimethyladenosine cap (m6A(m)) in U6 small nuclear RNA (snRNA), N(1)-methyladenine from tRNAs and internal m6A in mRNAs (PubMed:30197295). In the cytoplasm, mediates demethylation of m6A and m6A(m) in mRNAs and N(1)-methyladenine from tRNAs (PubMed:30197295). {ECO:0000269|PubMed:30197295}.
Mouse PG classificationLPG
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