| Gene Information | |
|---|---|
| Gene Name | PDK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 436 |
| Protein Names | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1) |
| Target Name | pyruvate dehydrogenase kinase 1 |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000152256 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q15118 |
| Gene Card | PDK1 |
| Uniprot ID | Q15118 |
| Pfam | PF10436; PF02518 |
| In ASD | no |
| Allosteric Prediction | yes (0.735695427) |
| Ortholog in Animals | Alpaca_ PDK1 ( ortholog_one2one ) Dog_ PDK1 ( ortholog_one2one ) GuineaPig_ PDK1 ( ortholog_one2one ) Macaque_ PDK1 ( ortholog_one2one ) Mouse_ Pdk1 ( ortholog_one2one ) Pig_ PDK1 ( ortholog_one2one ) Rat_ Pdk1 ( ortholog_one2one ) |
| Ohnologs | PDK4, PDK2 |
| Paralogs | PDK4, PDK2, PDK3, BCKDK |
| Tissue | NA |
| Tissue Specificity | Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas. {ECO:0000269|PubMed:7499431}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001390(Rat);0.018182(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2Q8F (X-ray 2.03A ) 2Q8G (X-ray 1.90A ) 2Q8H (X-ray 2.00A ) |
| DBSNP | rs35661499 rs34250425 |
| Subcellular location [CC] | Mitochondrion matrix {ECO:0000269|PubMed:22195962}. |
| Mouse PG classification | NA |
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