| Gene Information | |
|---|---|
| Gene Name | PDIA4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 645 |
| Protein Names | Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000155660 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P13667 |
| Gene Card | PDIA4 |
| Uniprot ID | P13667 |
| Pfam | PF00085 |
| In ASD | no |
| Allosteric Prediction | no (-0.593584733) |
| Ortholog in Animals | Alpaca_ PDIA4 ( ortholog_one2many ) GuineaPig_ PDIA4 ( ortholog_one2one ) Macaque_ PDIA4 ( ortholog_one2one ) Mouse_ Pdia4 ( ortholog_one2one ) Pig_ PDIA4 ( ortholog_one2one ) Rat_ Pdia4 ( ortholog_one2one ) Rabbit_ PDIA4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ERP27, PDIA6, TMX1, TXNDC11, TMX4, TMX3, PDILT, ERP44, PDIA2, PDIA3, PDIA5, P4HB, TXNDC5 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3IDV (X-ray 1.95A ) |
| DBSNP | rs2290971 |
| Subcellular location [CC] | Endoplasmic reticulum lumen {ECO:0000269|PubMed:12643545}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000269|PubMed:17081065}. |
| Mouse PG classification | NA |
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