| Gene Information | |
|---|---|
| Gene Name | PDIA3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 505 |
| Protein Names | Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) |
| Target Name | protein disulfide-isomerase a3 |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000167004 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P30101 |
| Gene Card | PDIA3 |
| Uniprot ID | P30101 |
| Pfam | PF00085 |
| In ASD | no |
| Allosteric Prediction | yes (0.499605351) |
| Ortholog in Animals | Alpaca_ PDIA3 ( ortholog_one2one ) Dog_ PDIA3 ( ortholog_one2one ) GuineaPig_ PDIA3 ( ortholog_one2one ) Macaque_ PDIA3 ( ortholog_one2many ) Mouse_ Pdia3 ( ortholog_one2one ) Pig_ PDIA3 ( ortholog_one2one ) Rat_ Pdia3 ( ortholog_one2one ) Rabbit_ PDIA3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ERP27, PDIA6, TMX1, TXNDC11, TMX4, TMX3, PDILT, ERP44, PDIA2, PDIA4, PDIA5, P4HB, TXNDC5 |
| Tissue | NA |
| Tissue Specificity | Detected in the flagellum and head region of spermatozoa (at protein level) (PubMed:20400973). Expressed in liver, stomach and colon (at protein level). Expressed in gastric parietal cells and chief cells (at protein level) (PubMed:24188822). {ECO:0000269|PubMed:20400973, ECO:0000269|PubMed:24188822}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.013793(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2ALB (NMR - ) 2DMM (NMR - ) 2H8L (X-ray 2.00A ) 3F8U (X-ray 2.60A ) 6ENY (EM 5.80A ) 7QPD (EM 3.73A ) |
| DBSNP | rs6413485 |
| Subcellular location [CC] | Endoplasmic reticulum {ECO:0000269|PubMed:23826168}. Endoplasmic reticulum lumen {ECO:0000250}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). {ECO:0000269|PubMed:12643545}. |
| Mouse PG classification | NA |
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