| Gene Information | |
|---|---|
| Gene Name | COLEC12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 742 |
| Protein Names | Collectin-12 (Collectin placenta protein 1) (CL-P1) (hCL-P1) (Nurse cell scavenger receptor 2) (Scavenger receptor class A member 4) (Scavenger receptor with C-type lectin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000158270 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q5KU26 |
| Gene Card | COLEC12 |
| Uniprot ID | Q5KU26 |
| Pfam | PF01391; PF00059 |
| In ASD | no |
| Allosteric Prediction | no (-0.52076082) |
| Ortholog in Animals | Alpaca_ COLEC12 ( ortholog_one2one ) Dog_ COLEC12 ( ortholog_one2one ) GuineaPig_ COLEC12 ( ortholog_one2one ) Macaque_ COLEC12 ( ortholog_one2one ) Mouse_ Colec12 ( ortholog_one2one ) Pig_ COLEC12 ( ortholog_one2one ) Rat_ Colec12 ( ortholog_one2one ) Rabbit_ COLEC12 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MARCO, SCARA5, MSR1 |
| Tissue | NA |
| Tissue Specificity | Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient. {ECO:0000269|PubMed:11162630, ECO:0000269|PubMed:11564734, ECO:0000269|PubMed:12761161, ECO:0000269|PubMed:16868960}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2OX8 (X-ray 2.50A ) |
| DBSNP | rs17855029 rs8098850 rs2305025 rs2305027 |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:11162630}; Single-pass type II membrane protein {ECO:0000269|PubMed:11162630}. Note=Forms clusters on the cell surface. |
| Mouse PG classification | NA |
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